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Sökning: id:"swepub:oai:DiVA.org:uu-166118" > Cdc6 expression rep...

Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

Sideridou, Maria (författare)
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, 11527 Athens, Greece
Zakopoulou, Roubini (författare)
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, 11527 Athens, Greece
Evangelou, Konstantinos (författare)
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, 11527 Athens, Greece
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Liontos, Michalis (författare)
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, 11527 Athens, Greece
Kotsinas, Athanassios (författare)
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, 11527 Athens, Greece
Rampakakis, Emmanouil (författare)
Goodman Cancer Center and Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
Gagos, Sarantis (författare)
Laboratory of Genetics, Academy of Athens, 11527 Athens, Greece
Kahata, Kaoru (författare)
Uppsala universitet,Ludwiginstitutet för cancerforskning
Grabusic, Kristina (författare)
Department of Molecular Medicine and Biotechnology, School of Medicine, University of Rijeka, HR-51000 Rijeka, Croatia
Gkouskou, Kalliopi (författare)
Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Crete, Greece
Trougakos, Ioannis P (författare)
Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, GR-15784 Athens, Greece
Kolettas, Evangelos (författare)
Cell and Molecular Physiology Unit, Department of Physiology, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
Georgakilas, Alexandros G (författare)
Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858
Volarevic, Sinisa (författare)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
Eliopoulos, Aristides G (författare)
Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Crete, Greece
Zannis-Hadjopoulos, Maria (författare)
Goodman Cancer Center and Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
Moustakas, Aristidis (författare)
Uppsala universitet,Ludwiginstitutet för cancerforskning,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
Gorgoulis, Vassilis G (författare)
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, 11527 Athens, Greece
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 (creator_code:org_t)
2011-12-26
2011
Engelska.
Ingår i: Journal of Cell Biology. - : Rockefeller University Press. - 0021-9525 .- 1540-8140. ; 195:7, s. 1123-1140
Relaterad länk:
http://jcb.rupress.o...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • E-cadherin (CDH1) loss occurs frequently in carcinogenesis, contributing to invasion and metastasis. We observed that mouse and human epithelial cell lines overexpressing the replication licensing factor Cdc6 underwent phenotypic changes with mesenchymal features and loss of E-cadherin. Analysis in various types of human cancer revealed a strong correlation between increased Cdc6 expression and reduced E-cadherin levels. Prompted by these findings, we discovered that Cdc6 repressed CDH1 transcription by binding to the E-boxes of its promoter, leading to dissociation of the chromosomal insulator CTCF, displacement of the histone variant H2A.Z, and promoter heterochromatinization. Mutational analysis identified the Walker B motif and C-terminal region of Cdc6 as essential for CDH1 transcriptional suppression. Strikingly, CTCF displacement resulted in activation of adjacent origins of replication. These data demonstrate that Cdc6 acts as a molecular switch at the E-cadherin locus, linking transcriptional repression to activation of replication, and provide a telling example of how replication licensing factors could usurp alternative programs to fulfill distinct cellular functions.

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