Optimising islet engraftment is critical for successful clinical islet transplantation

• Clinical islet transplantation is currently being explored as a treatment for persons with type 1 diabetes and hypoglycaemia unawareness. Although 'proof-of-principle' has been established in recent clinical studies, the procedure suffers from low efficacy. At the time of transplantation, the isolated islets are allowed to embolise the liver after injection in the portal vein, a procedure that is unique in the area of transplantation. A novel view on the engraftment of intraportally transplanted islets is presented that could explain the low efficacy of the procedure.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

Clinical

Engraftment

Innate immunity

Intraportal

Intramuscular

Islet transplantation

Liver morphology

Thrombosis

Tumour metastasis

Revascularisation

MEDICINE

MEDICIN

tumour metastasis

revascularisation

thrombosis

liver morphology

islet transplantation

intramuscular

intraportal

innate immunity

clinical

engraftment

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)