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STOX2 but not STOX1...
STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women : data from the Second Nord-Trondelag Health Study
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Fenstad, M H (författare)
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Johnson, M P (författare)
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Løset, M (författare)
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Mundal, S B (författare)
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Roten, L T (författare)
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Eide, I P (författare)
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Bjørge, L (författare)
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Sande, R K (författare)
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- Johansson, Åsa (författare)
- Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim 7006, Norway
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Dyer, T D (författare)
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Forsmo, S (författare)
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Blangero, J (författare)
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Moses, E K (författare)
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Austgulen, R (författare)
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(creator_code:org_t)
- 2010-07-19
- 2010
- Engelska.
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Ingår i: Molecular human reproduction. - : Oxford University Press (OUP). - 1360-9947 .- 1460-2407. ; 16:12, s. 960-968
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Variation in the Storkhead box-1 (STOX1) gene has previously been associated with pre-eclampsia. In this study, we assess candidate single nucleotide polymorphisms (SNPs) in STOX1 in an independent population cohort of pre-eclamptic (n = 1.139) and non-pre-eclamptic (n = 2.269) women (the HUNT2 study). We also compare gene expression levels of STOX1 and its paralogue, Storkhead box-2 (STOX2) in decidual tissue from pregnancies complicated by pre-eclampsia and/or fetal growth restriction (FGR) (n = 40) to expression levels in decidual tissue from uncomplicated pregnancies (n = 59). We cannot confirm association of the candidate SNPs to pre-eclampsia (P > 0.05). For STOX1, no differential gene expression was observed in any of the case groups, whereas STOX2 showed significantly lower expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls (P = 0.01). We further report a strong correlation between transcriptional alterations reported previously in choriocarcinoma cells over expressing STOX1A and alterations observed in decidual tissue of pre-eclamptic women with FGR.
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Fenstad, M H
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Johnson, M P
-
Løset, M
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Mundal, S B
-
Roten, L T
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Eide, I P
-
visa fler...
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Bjørge, L
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Sande, R K
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Johansson, Åsa
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Dyer, T D
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Forsmo, S
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Blangero, J
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Moses, E K
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Austgulen, R
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visa färre...
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Molecular human ...
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Uppsala universitet