Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview

• HIV-1 protease has a broad and complex substrate specificity, which hitherto has escaped a simple comprehensive definition. This, and the relatively high mutation rate of the retroviral protease, makes it challenging to design effective protease inhibitors. Several attempts have been made during the last two decades to elucidate the enigmatic cleavage specificity of HIV-1 protease and to predict cleavage of novel substrates using bioinformatic analysis methods. This review describes the methods that have been utilized to date to address this important problem and the results achieved. The data sets used are also reviewed and important aspects of these are highlighted.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

Computational Biology/*methods/*trends

HIV-1/*enzymology

Humans

Models; Chemical

Peptide Hydrolases/*chemistry/*metabolism

Substrate Specificity/physiology

MEDICINE

MEDICIN

protease

prediction

human immunodeficiency virus

HIV

bioinformatics

cleavage rule

physicochemical property

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)