Prediction of warfarin dose : why, when and how?

• Prediction models are the key to individualized drug therapy. Warfarin is a typical example of where pharmacogenetics could help the individual patient by modeling the dose, based on clinical factors and genetic variation in CYP2C9 and VKORC1. Clinical studies aiming to show whether pharmacogenetic warfarin dose predictions are superior to conventional initiation of warfarin are now underway. This review provides a broad view over the field of warfarin pharmacogenetics from basic knowledge about the drug, how it is monitored, factors affecting dose requirement, prediction models in general and different types of prediction models for warfarin dosing.

Nyckelord

dosing algorithm

human CYP2C9 protein

human VKORC1 protein

pharmacogenetics models

statistical regression analysis

warfarin

Clinical Pharmacology

Klinisk farmakologi

Publikations- och innehållstyp

ref (ämneskategori)

for (ämneskategori)