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Entourage : the immune microenvironment following follicular lymphoma
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- Wahlin, B. E. (författare)
- Karolinska Institutet
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- Sander, B. (författare)
- Karolinska Institutet
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- Christensson, B. (författare)
- Karolinska Institutet
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Ostenstad, B. (författare)
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Holte, H. (författare)
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Brown, P. D. (författare)
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- Sundström, Christer (författare)
- Uppsala universitet,Molekylär och morfologisk patologi,Alafuzoff
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- Kimby, E. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2012-01-20
- 2012
- Engelska.
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Ingår i: Blood Cancer Journal. - : Springer Science and Business Media LLC. - 2044-5385. ; 2, s. e52-
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- In follicular lymphoma, nonmalignant immune cells are important. Follicular lymphoma depends on CD4+ cells, but CD8+ cells counteract it. We hypothesized that the presence of follicular lymphoma is associated with higher CD4+ than CD8+ cell numbers in the tumor microenvironment but not in the immune system. Using flow cytometry, pre-treatment and follow-up CD4/CD8 ratios were estimated in the bone marrow, blood and lymph nodes of untreated follicular lymphoma patients in two independent data sets (N-1 = 121; N-2 = 166). The ratios were analyzed for their relation with bone marrow lymphoma involvement. Bone marrows were also investigated with immunohistochemistry. In either data set, the bone marrow CD4/CD8 ratios were higher in bone marrows involved with lymphoma (P = 0.043 and 0.0002, respectively). The mean CD4/CD8 ratio was 1.0 in uninvolved and 1.4 in involved bone marrows. Also higher in involved bone marrows were CD4/CD56 and CD3CD25/CD3 ratios. No blood or lymph node ratios differed between bone marrow-negative and -positive patients. Sequential samples showed increased bone marrow CD4/CD8 ratios in all cases of progression to bone marrow involvement. Immunohistochemistry showed CD4+, CD57+, programmed death-1+, forkhead box protein 3+ and CD21+ cells accumulated inside the lymphoma infiltrates, whereas CD8+, CD56+ and CD68+ cells were outside the infiltrates. This study provides evidence in vivo that the microenvironment changes upon follicular lymphoma involvement.
Nyckelord
- follicular lymphoma
- microenvironment
- bone marrow
- CD4/CD8 ratio
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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