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Linkage study of em...
Linkage study of embryopathy-Polygenic inheritance of diabetes-induced skeletal malformations in the rat
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- Nordquist, Niklas (författare)
- Uppsala universitet,Farmakologi
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- Luthman, Holger (författare)
- Lund University,Lunds universitet,Genetik,Forskargrupper vid Lunds universitet,Genetics,Lund University Research Groups
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- Pettersson, Ulf (författare)
- Uppsala universitet,Genomik
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- Eriksson, Ulf J. (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- Engelska.
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Ingår i: Reproductive Toxicology. - : Elsevier BV. - 0890-6238 .- 1873-1708. ; 33:3, s. 297-307
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- We developed an inbred rat model of diabetic embryopathy, in which the offspring displays skeletal malformations (agnathia or micrognathia) when the mother is diabetic, and no malformations when she is not diabetic. Our aim was to find genes controlling the embryonic maldevelopment in a diabetic environment. We contrasted the fetal outcome in inbred Sprague-Dawley L rats (20% skeletal malformations in diabetic pregnancy) with that of inbred Wistar Furth rats (denoted W, no skeletal malformations in diabetic pregnancy). We used offspring from the backcross F-1 x L to probe for the genetic basis for malformation of the mandible in diabetic pregnancy. A set of 186 fetuses (93 affected, 93 unaffected) was subjected to a whole genome scan with 160 micro satellites. Analysis of genotype distribution indicated 7 loci on chromosome 4, 10 (3 loci), 14, 18, and 19 in the teratogenic process (and 14 other loci on 12 chromosomes with less strong association to the malformations), several of which contained genes implicated in other experimental studies of diabetic embryopathy. These candidate genes will be scrutinized in further experimentation. We conclude that the genetic involvement in rodent diabetic embryopathy is polygenic and predisposing for congenital malformations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Rat
- Diabetes-in-pregnancy
- Streptozotocin
- Congenital anomalies
- Mandible
- Whole genome scan
- Micro satellites
- Genetic predisposition
- Rat
- Diabetes-in-pregnancy
- Streptozotocin
- Congenital anomalies
- Mandible
- Whole genome scan
- Micro satellites
- Genetic predisposition
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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