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Microwave-assisted ...
Microwave-assisted transition-metal-catalyzed synthesis of N-shifted and ring-expanded buflavine analogues
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- Appukkuttan, Prasad (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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Dehaen, Wim (författare)
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Van der Eycken, Erik (författare)
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(creator_code:org_t)
- Wiley, 2007
- 2007
- Engelska.
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Ingår i: Chemistry - A European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 13:22, s. 6452-6460
- Relaterad länk:
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http://www.ncbi.nlm....
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visa fler...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Two novel and efficient strategies for the synthesis of hitherto unknown N-shifted and ring-expanded buflavine analogues are presented. Construction of the medium-sized ring system of the title molecules, a difficult task due to the high activation energy needed for the ring-closure with the additional rigidity imposed by the biaryl skeleton, was achieved by using Suzuki-Miyaura biaryl coupling and a ring-closing metathesis reaction as the key steps. The combination of a second-generation Grubbs catalyst and microwave irradiation proved to be highly useful in generating the otherwise difficult to obtain medium-sized ring system of the buflavine analogues.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- buflavine
- cross-coupling
- medium-sized rings
- metathesis
- microwave irradiation
- PHARMACY
- FARMACI
Publikations- och innehållstyp
- vet (ämneskategori)
- art (ämneskategori)
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