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Patterns of metasta...
Patterns of metastasis in women with metachronous contralateral breast cancer
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Vichapat, V. (författare)
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Garmo, Hans (författare)
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- Holmberg, Lars (författare)
- Uppsala universitet,Endokrinkirurgi
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Fentiman, I. S. (författare)
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Tutt, A. (författare)
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Gillett, C. (författare)
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Luechtenborg, M. (författare)
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(creator_code:org_t)
- 2012-06-26
- 2012
- Engelska.
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 107:2, s. 221-223
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The understanding of metastatic patterns after metachronous contralateral breast cancer (CBC) may help determine the biological nature of CBC.METHODS: A cohort of 8478 women with breast cancer treated at Guy's and St Thomas' NHS Foundation Trust between 1975 and 2006 were studied. Organ-specific 5-year cumulative incidence and incidence rate ratios were assessed for women diagnosed with unilateral breast cancer (UBC), CBC within 5 years and CBC more than 5 years of the initial diagnosis.RESULTS: Women diagnosed with CBC within 5 years had a higher incidence of metastases in all organs compared with UBC. Women with a short interval time to CBC developed metastasis more rapidly and were more likely to develop visceral and distant cutaneous metastases compared with bone metastasis.CONCLUSION: These findings explain poor prognosis of women with early occurring CBC and suggest that some of these CBCs are indicators of aggressive and/or systemic disease.
Nyckelord
- metachronous cancer
- contralateral breast cancer
- patterns of metastasis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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