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Viral and Molecular...
Viral and Molecular Aspects of Oral Cancer
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- Hillbertz, Nicolette Salmon (författare)
- Uppsala universitet,Käkkirurgi
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- Hirsch, Jan-Michael (författare)
- Uppsala universitet,Käkkirurgi
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Jalouli, Jamshid (författare)
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visa fler...
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- Jalouli, Miranda M. (författare)
- Uppsala universitet,Käkkirurgi
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- Sand, Lars (författare)
- Uppsala universitet,Käkkirurgi
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visa färre...
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(creator_code:org_t)
- 2012
- 2012
- Engelska.
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 32:10, s. 4201-4212
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Squamous cell carcinoma (SCC) is the most common epithelial malignancy in the oral cavity. SCCs and their variants constitute over 90% of oral malignancies, and the disease is associated with poor prognosis. OSCC is a complex malignancy where environmental factors, virus infections, and genetic alterations most likely interact, and thus give rise to the malignant condition. Herein, we review the available literature regarding high-risk factors such as alcohol and tobacco usage; discuss the roles of human papillomaviruses (HPV), the Epstein-Barr virus, and the human herpes simplex virus (HSV); and evaluate several candidate genes associated with the condition: p53, p16(INK4) and p21(WAF1/CIP1) survivin, B-cell lymphoma-2 (BCL-2), keratins, Fibroblast growth factor 3 (FGF3), FGF4, FGF19, Oral cancer overexpressed gene 1 (ORAOV1), and Cyclin D1 (CCND1).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Oral cancer
- tobacco
- HPV
- EBV
- HSV-1
- p53
- p16(INK4A) and p21(WAF1/CIP1)
- survivin
- BCL-2
- keratins
- FGF3
- FGF4
- FGF19
- ORAOV1
- CCND1
- review
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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