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Blood flow in endog...
Blood flow in endogenous and transplanted pancreatic islets in anesthetized rats : Effects of lactate and pyruvate
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- Barbu, Andreea (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Endokrin tumörbiologi
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- Johansson, Åsa (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Bodin, Bbirgitta (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Källskog, Örjan (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Carlsson, Per-Ola (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Endokrin diabetes och metabolism
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- Sandberg, Monica (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Börjesson, Joey Lau (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Jansson, Leif (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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(creator_code:org_t)
- 2012
- 2012
- Engelska.
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Ingår i: Pancreas. - 0885-3177 .- 1536-4828. ; 41:8, s. 1263-1271
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: The objective of this study was to evaluate the effects of exogenously administered lactate and pyruvate on blood perfusion in endogenous and transplanted islets. METHODS: Anesthetized Wistar-Furth rats were given lactate or pyruvate intravenously, and regional blood perfusion was studied 3 or 30 minutes later with a microsphere technique. Separate rats received a 30-minute infusion of pyruvate or lactate into the portal vein before blood flow measurements. We also administered these substances to islet-implanted rats 4 weeks after transplantation and measured graft blood flow with laser Doppler flowmetry. The expression of monocarboxylate transporter 1 and lactate dehydrogenase A was analyzed. RESULTS: The expression of monocarboxylate transporter 1 and lactate dehydrogenase A was markedly up-regulated in transplanted as compared with endogenous islets. Administration of pyruvate, but not lactate, increased mesenteric blood flow after 3 minutes. Pyruvate decreased mesenteric blood flow after 30 minutes, whereas lactate decreased only islet blood flow. These responses were absent in transplanted animals. A continuous intraportal infusion of lactate or pyruvate increased selectively islet blood flow but did not affect blood perfusion of transplanted islets. CONCLUSIONS: Lactate and pyruvate affect islet blood flow through effects mediated by interactions between the liver and the nervous system. Such a response can help adjust the release of islet hormones during excess substrate concentrations.
Nyckelord
- blood flow
- lactate
- pancreatic islets
- pyruvate
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Pancreas
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