Search: id:"swepub:oai:DiVA.org:uu-187797" >
Imidazopyridine-bas...
Imidazopyridine-based inhibitors of glycogen synthase kinase 3 : synthesis and evaluation of amide isostere replacements of the carboxamide scaffold
-
Yngve, Ulrika (author)
-
Söderman, Peter (author)
-
Svensson, Mats (author)
-
show more...
-
Rosqvist, Susanne (author)
-
- Arvidsson, Per I (author)
- Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
-
show less...
-
(creator_code:org_t)
- 2012-11-19
- 2012
- English.
-
In: Chemistry and Biodiversity. - : Wiley. - 1612-1872 .- 1612-1880. ; 9:11, s. 2442-2452
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- In this study, we explored the effect of bioisostere replacement in a series of glycogen synthase kinase 3 (GSK3) inhibitors based on the imidazopyridine core. The synthesis and biological evaluation of a number of novel sulfonamide, 1,2,4-oxadiazole, and thiazole derivates as amide bioisosteres, as well as a computational rationalization of the obtained results are reported.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database