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Stool cultures obta...
Stool cultures obtained before liver transplantation are useful for choice of perioperative antibiotic prophylaxis
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Barkholt, L M (författare)
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Andersson, J (författare)
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- Ericzon, B G (författare)
- Karolinska Institutet
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Palmgren, A C (författare)
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Broomé, U (författare)
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- Duraj, Frans (författare)
- Karolinska Institute, Huddinge University Hospital, Sweden
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- Bergquist, A (författare)
- Karolinska Institutet
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Herlenius, G (författare)
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- Nord, C E (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Frontiers Media SA, 1997
- 1997
- Engelska.
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Ingår i: Transplant International. - : Frontiers Media SA. - 0934-0874 .- 1432-2277. ; 10:6, s. 432-438
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Bacterial infections, especially cholangitis, are still common complications after liver transplantation (LTx). During recent years, multiresistant enterococci have become a nosocomial problem in transplant units. The present prospective study on 26 patients, including 24 patients with chronic liver disease, demonstrated that enterococci were the predominant micro-organism involved in post-LTx bacterial infections. They were cultured in the feces and in other sites of 10 out of 13 (77%) patients who underwent extensive examinations. Ampicillin-resistant Enterococcus faecium strains were isolated in urine or feces of 2 of the 13 patients prior to LTx. Similarly, resistance to ampicillin and gentamicin, the empirically used antibiotics for patients with fever of unknown origin, was found in E. faecium strains in 3 and 2 patients, respectively. Moreover, multiresistant E. faecium and E. faecalis strains were demonstrated in 46% of the patients in the postoperative period (3 months). However, no vancomycin-resistant enterococci were isolated. The use of antibiotics within 4 months prior to LTx significantly increased the risk of developing ampicillin-resistant bacteria at the time of LTx and of infections with bacteria of enteric origin after LTx (P = 0.03 and 0.01, respectively). We conclude that stool and urine cultures performed prior to LTX may be useful for selecting prophylactic antibiotic regimens.
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