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Premenstrual dyspho...
Premenstrual dysphoric disorder and prefrontal reactivity during anticipation of emotional stimuli
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- Gingnell, Malin (författare)
- Uppsala universitet,Obstetrik & gynekologi,Institutionen för psykologi,Reproduktiv hälsa/Sundström Poromaa
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- Bannbers, Elin, 1984- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa
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- Wikström, Johan (författare)
- Uppsala universitet,Enheten för radiologi
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- Fredrikson, Mats (författare)
- Uppsala universitet,Institutionen för psykologi
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- Sundström Poromaa, Inger, 1964- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- Engelska.
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Ingår i: European Neuropsychopharmacology. - : Elsevier BV. - 0924-977X .- 1873-7862. ; 23:11, s. 1474-1483
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Premenstrual disorder (PMDD) affects around 5% of women in childbearing ages. An increased sensitivity in emotion processing areas of the brain to variations in ovarian steroid levels has been suggested as part of the pathophysiology in PMDD, but prior neuroimaging studies of emotion processing are yet inconclusive. Previous behavioral studies of women with PMDD have, however, reported enhanced luteal phase startle responsivity during emotional anticipation. Here we used functional magnetic resonance imaging (fMRI) to investigate central neural circuitry activity during anticipation of, and exposure to, emotional stimuli across the menstrual cycle in women with and without PMDD. As compared to healthy controls, women with PMDD displayed significantly enhanced reactivity in the prefrontal cortex during anticipation of, but not exposure to, negative emotional stimuli during the luteal phase. In PMDD patients, BOLD reactivity during anticipation or viewing of negative emotional stimuli was not dependent on absolute levels of estradiol or progesterone. However, progesterone levels were positively correlated with emotion-induced reactivity in the dorsolateral prefrontal cortex to positive emotional stimuli. These findings suggest that cortical emotional circuitry reactivity during anticipation is altered in PMDD during the luteal phase, which might be part of the pathophysiology behind the emotional symptoms or lack of emotional control reported by women with PMDD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- fMRI
- premenstrual dysphoric disorder
- progesterone
- estrogen
- anticipation
- emotion
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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