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Dose-densified chem...
Dose-densified chemoimmunotherapy followed by systemic central nervous system prophylaxis for younger high-risk diffuse large B-cell/follicular grade 3 lymphoma patients : results of a phase II Nordic Lymphoma Group study
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Holte, H. (author)
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Leppa, S. (author)
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- Bjorkholm, M. (author)
- Karolinska Institutet
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Fluge, O. (author)
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Jyrkkio, S. (author)
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Delabie, J. (author)
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- Sundström, Christer (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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Karjalainen-Lindsberg, M. -L (author)
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- Eriksson, Mikael (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Kolstad, A. (author)
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Fossa, A. (author)
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Ostenstad, B. (author)
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Lofvenberg, E. (author)
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Nordstrom, M. (author)
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Janes, R. (author)
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Pedersen, L. M. (author)
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- Anderson, Harald (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Erlanson, Martin (author)
- Umeå universitet,Onkologi
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 24:5, s. 1385-1392
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Abstract
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- Background: Many patients with aggressive B-cell lymphomas and high clinical risk score still die of lymphoma after conventional R-CHOP chemoimmunotherapy. We hypothesized that intensified chemoimmunotherapy including systemic central nervous system (CNS) prophylaxis improves outcome and reduces the incidence of CNS-related events. Patients and methods: Inclusion criteria were age 18-65 years, primary diffuse large B-cell lymphoma or grade III follicular lymphoma without clinical signs of CNS disease and negative cerebrospinal fluid cytology, age-adjusted International Prognostic Index 2-3 and WHO performance score 0-3. Treatment consisted of six courses of R-CHOEP-14 followed by a course of high-dose cytarabine and a course of high-dose methotrexate. Primary end point was failure-free survival (FFS) at 3 years. Results: A total of 156 eligible patients with a median age of 54 years (range 20-64) were included. Three toxic deaths were observed. Three-year overall survival (OS) and FFS rates (median observation time 52 months for survivors) were 81% and 65%, respectively. Seven patients experienced CNS relapse, all within 6 months. Conclusions: The results are promising with favorable 3-year OS and FFS rates, a low toxic death rate and a lower than expected number of CNS events. CNS progression might be further reduced by earlier CNS prophylaxis. CinicalTrials.gov.identifier: NCT01502982.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- age-adjusted IPI
- central nervous system
- diffuse large B-cell lymphoma
- intensive chemotherapy
- prophylaxis
- age-adjusted IPI
- central nervous system
- diffuse large B-cell lymphoma
- intensive chemotherapy
- prophylaxis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Holte, H.
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Leppa, S.
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Bjorkholm, M.
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Fluge, O.
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Jyrkkio, S.
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Delabie, J.
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show more...
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Sundström, Chris ...
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Karjalainen-Lind ...
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Eriksson, Mikael
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Kolstad, A.
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Fossa, A.
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Ostenstad, B.
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Lofvenberg, E.
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Nordstrom, M.
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Janes, R.
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Pedersen, L. M.
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Anderson, Harald
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Jerkeman, Mats
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Erlanson, Martin
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Annals of Oncolo ...
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet
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Umeå University