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Prevalence and clin...
Prevalence and clinical outcomes of undiagnosed diabetes mellitus and prediabetes among patients with high-risk non-ST-segment elevation acute coronary syndrome
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Giraldez, Roberto R. (author)
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Clare, Robert M. (author)
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Lopes, Renato D. (author)
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Dalby, Anthony J. (author)
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Prabhakaran, Dorairaj (author)
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Brogan, Gerard X., Jr. (author)
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Giugliano, Robert P. (author)
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- James, Stefan K. (author)
- Uppsala universitet,Kardiologi
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Tanguay, Jean-Francois (author)
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Pollack, Charles V., Jr. (author)
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Harrington, Robert A. (author)
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Braunwald, Eugene (author)
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Newby, L. Kristin (author)
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 165:6, s. 918-925.e2
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background We examined the prevalence of undiagnosed diabetes or prediabetes and associations with ischemic outcomes among non-ST-segment elevation acute coronary syndrome (ACS) patients. Methods We categorized 8795 EARLY ACS trial patients into one of the following groups: "known diabetes" (n = 2860 [32.5%]; reported on the case report form), "undiagnosed diabetes" (n = 1069 [12.2%]; no diabetes history and fasting glucose >= 126 mg/dL or hemoglobin A(1c) >= 6.5%), "prediabetes" (n = 947 [10.8%]; fasting glucose >= 110 to <126 mg/dL, or " normal" (n = 3919 [44.5%]). Adjusted associations of known diabetes, undiagnosed diabetes, and prediabetes (versus normal) with 30-day and 1-year outcomes were determined. Results Undiagnosed diabetes was associated with greater 30-day death or myocardial infarction (MI) (ORadj 1.28, 95% CI 1.05-1.57), driven primarily by greater 30-day mortality (ORadj 1.65, 95% CI 1.09-2.48). Known diabetic patients had 30-day death or MI outcomes similar to those of normal patients, but 30-day mortality was higher (ORadj 1.40, 95% CI 1.01-1.93). Prediabetic patients had 30-day death or MI outcomes similar to those of normal patients. One-year mortality was greater among known diabetic patients (HRadj 1.38, 95% CI 1.13-1.67) but not among those with undiagnosed diabetes or prediabetes. Conclusions Undiagnosed diabetes and prediabetes were common among high-risk non-ST-segment elevation ACS patients. Routine screening for undiagnosed diabetes may be useful since these patients seem to have worse short-term outcomes and deserve consideration of alternative management strategies.
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Giraldez, Robert ...
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Clare, Robert M.
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Lopes, Renato D.
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Dalby, Anthony J ...
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Prabhakaran, Dor ...
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Brogan, Gerard X ...
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show more...
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Giugliano, Rober ...
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James, Stefan K.
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Tanguay, Jean-Fr ...
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Pollack, Charles ...
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Harrington, Robe ...
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Braunwald, Eugen ...
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Newby, L. Kristi ...
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show less...
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American Heart J ...
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Uppsala University