Sökning: id:"swepub:oai:DiVA.org:uu-204274" >
Acute Sleep Restric...
Acute Sleep Restriction Reduces Insulin Sensitivity in Adolescent Boys
-
Klingenberg, Lars (författare)
-
Chaput, Jean-Philippe (författare)
-
- Holmbäck, Ulf (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
-
visa fler...
-
Visby, Trine (författare)
-
Jennum, Poul (författare)
-
Nikolic, Miki (författare)
-
Astrup, Arne (författare)
-
Sjodin, Anders (författare)
-
visa färre...
-
(creator_code:org_t)
- 2013-07-01
- 2013
- Engelska.
-
Ingår i: Sleep. - : Oxford University Press (OUP). - 0161-8105 .- 1550-9109. ; 36:7, s. 1085-1090
- Relaterad länk:
-
https://academic.oup...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.5...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Short sleep duration has been linked to impaired glucose metabolism in many experimental studies. Moreover, studies have reported indications of an increased metabolic stress following sleep restriction. Objective: We aimed to investigate the effects of partial sleep deprivation on markers of glucose metabolism. Additionally, we aimed to investigate if short sleep duration induces a state of endocrine stress. Design: A randomized crossover design, with 2 experimental conditions: 3 consecutive nights of short sleep (SS, 4 h/night) and long sleep (LS, 9 h/night) duration. Subjects and Measurements: In 21 healthy, normal-weight male adolescents (mean +/- SD age: 16.8 +/- 1.3 y) we measured pre- and post-prandial glucose, insulin, C-peptide, and glucagon concentrations. Furthermore, we measured fasting cortisol, 24-h catecholamines, and sympathovagal balance. Results: Fasting insulin was 59% higher (P = 0.001) in the SS than the LS condition as was both fasting (24%, P < 0.001) and post-prandial (11%, P = 0.018) C-peptide. Pre- and post-prandial glucose and glucagon were unchanged between conditions. The homeostasis model assessment of insulin resistance (HOMA-IR) index was 65% higher (P = 0.002) and the Matsuda index was 28% lower (P = 0.007) in the SS condition compared to the LS condition. The awakening cortisol response and 24-h norepinephrine were not affected by sleep duration, whereas 24-h epinephrine was 24% lower (P = 0.013) in the SS condition. Neither daytime nor 24-h sympathovagal balance differed between sleep conditions. Short wave sleep was preserved in the SS condition. Conclusion: Short-term sleep restriction is associated with decreased insulin sensitivity in healthy normal-weight adolescent boys. There were no indications of endocrine stress beyond this.
Nyckelord
- Sleep deprivation
- sleep quality
- glucose metabolism
- teenagers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Sleep
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas