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Renal Effects of Le...
Renal Effects of Levosimendan : A Consensus Report
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Yilmaz, Mehmet B. (author)
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Grossini, Elena (author)
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Silva Cardoso, Jose C. (author)
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Edes, Istvan (author)
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Fedele, Francesco (author)
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Pollesello, Piero (author)
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Kivikko, Matti (author)
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Harjola, Veli-Pekka (author)
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Hasslacher, Julia (author)
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Mebazaa, Alexandre (author)
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Morelli, Andrea (author)
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le Noble, Jos (author)
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- Oldner, Anders (author)
- Karolinska Institutet
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Oulego Erroz, Ignacio (author)
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Parissis, John T. (author)
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Parkhomenko, Alexander (author)
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Poelzl, Gerhard (author)
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Rehberg, Sebastian (author)
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- Ricksten, Sven-Erik, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
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Rodriguez Fernandez, Luis M. (author)
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Salmenpera, Markku (author)
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Singer, Mervyn (author)
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Treskatsch, Sascha (author)
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Vrtovec, Bojan (author)
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- Wikström, Gerhard (author)
- Uppsala universitet,Kardiologi
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(creator_code:org_t)
- 2013-08-09
- 2013
- English.
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In: Cardiovascular Drugs and Therapy. - : Springer Science and Business Media LLC. - 0920-3206 .- 1573-7241. ; 27:6, s. 581-590
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Abstract
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- Renal dysfunction is common in clinical settings in which cardiac function is compromised such as heart failure, cardiac surgery or sepsis, and is associated with high morbidity and mortality. Levosimendan is a calcium sensitizer and potassium channel opener used in the treatment of acute heart failure. This review describes the effects of the inodilator levosimendan on renal function. A panel of 25 scientists and clinicians from 15 European countries (Austria, Finland, France, Hungary, Germany, Greece, Italy, Portugal, the Netherlands, Slovenia, Spain, Sweden, Turkey, the United Kingdom, and Ukraine) convened and reached a consensus on the current interpretation of the renal effects of levosimendan described both in non-clinical research and in clinical study reports. Most reports on the effect of levosimendan indicate an improvement of renal function in heart failure, sepsis and cardiac surgery settings. However, caution should be applied as study designs differed from randomized, controlled studies to uncontrolled ones. Importantly, in the largest HF study (REVIVE I and II) no significant changes in the renal function were detected. As it regards the mechanism of action, the opening of mitochondrial K-ATP channels by levosimendan is involved through a preconditioning effect. There is a strong rationale for randomized controlled trials seeking beneficial renal effects of levosimendan. As an example, a study is shortly to commence to assess the role of levosimendan for the prevention of acute organ dysfunction in sepsis (LeoPARDS).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- Levosimendan
- Renal dysfunction
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Yilmaz, Mehmet B ...
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Grossini, Elena
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Silva Cardoso, J ...
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Edes, Istvan
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Fedele, Francesc ...
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Pollesello, Pier ...
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show more...
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Kivikko, Matti
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Harjola, Veli-Pe ...
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Hasslacher, Juli ...
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Mebazaa, Alexand ...
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Morelli, Andrea
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le Noble, Jos
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Oldner, Anders
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Oulego Erroz, Ig ...
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Parissis, John T ...
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Parkhomenko, Ale ...
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Poelzl, Gerhard
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Rehberg, Sebasti ...
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Ricksten, Sven-E ...
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Rodriguez Fernan ...
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Salmenpera, Mark ...
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Singer, Mervyn
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Treskatsch, Sasc ...
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Vrtovec, Bojan
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Wikström, Gerhar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
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Cardiovascular D ...
- By the university
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Uppsala University
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University of Gothenburg
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Karolinska Institutet