Sökning: id:"swepub:oai:DiVA.org:uu-220706" >
Circulating Human F...
Circulating Human Fractalkine is Decreased Post-operatively After Orthopedic and Coronary Bypass Surgery
-
- Åkerfeldt, Torbjörn (författare)
- Uppsala universitet,Biokemisk endokrinologi
-
- Helmersson-Karlqvist, Johanna (författare)
- Uppsala universitet,Biokemisk struktur och funktion
-
- Gordh, Torsten (författare)
- Uppsala universitet,Anestesiologi och intensivvård
-
visa fler...
-
- Larsson, Anders (författare)
- Uppsala universitet,Biokemisk struktur och funktion
-
visa färre...
-
(creator_code:org_t)
- 2014
- 2014
- Engelska.
-
Ingår i: In Vivo. - 0258-851X .- 1791-7549. ; 28:2, s. 185-188
- Relaterad länk:
-
https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Fractalkine is an important chemokine involved in resolving normal inflammatory processes such as wound healing. Soluble fractalkine acts as a chemoattractant bringing cytotoxic and cytokine-producing cells to areas of inflammation. The aim of the present study was to investigate circulating fractalkine during inflammatory response induced by surgery.MATERIALS AND METHODS: Fractalkine was analyzed in serum samples from orthopedic surgery patients (n=29) and coronary bypass patients (n=21). The samples were collected prior to surgery and 4 and 30 days after surgery, respectively.RESULTS: Fractalkine concentrations decreased from pre-operative levels of 1,764 (1,330-2,434) pg/mL to 1,520 (1,330-2,434) pg/mL at 4 days after surgery, and to 1,285 (1,099-1,462) pg/mL 30 days after surgery in patients undergoing orthopedic procedures (p<0.01, 30 days post-operatively versus pre-operatively). Furthermore, fractalkine concentrations decreased significantly from pre-operative levels of 1,856 (1,520-2,434) pg/mL to 1,338 (964-1,650) pg/mL 4 days post-operatively and to 1,266 (1,080-1,338) pg/mL 30 days post-operatively in patients undergoing coronary bypass surgery (p<0.01, 30 days post-operative versus pre-operative values).CONCLUSION: A significant and persistent decrease in circulating fractalkine was observed after orthopedic and coronary bypass surgery despite a marked inflammatory response.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
In Vivo
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas