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Genome-wide and gen...
Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease
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Hong, Mun-Gwan (författare)
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Reynolds, Chandra A (författare)
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- Feldman, Adina L (författare)
- Karolinska Institutet
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Kallin, Mikael (författare)
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Lambert, Jean-Charles (författare)
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Amouyel, Philippe (författare)
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- Ingelsson, Erik, 1975- (författare)
- Karolinska Institutet
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- Pedersen, Nancy L (författare)
- Karolinska Institutet
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- Prince, Jonathan A (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2012-01-23
- 2012
- Engelska.
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Ingår i: Human Mutation. - : Hindawi Limited. - 1059-7794 .- 1098-1004. ; 33:3, s. 521-529
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Genome-wide association studies (GWAS) that allow for allelic heterogeneity may facilitate the discovery of novel genes not detectable by models that require replication of a single variant site. One strategy to accomplish this is to focus on genes rather than markers as units of association, and so potentially capture a spectrum of causal alleles that differ across populations. Here, we conducted a GWAS of Alzheimer disease (AD) in 2,586 Swedes and performed gene-based meta-analysis with three additional studies from France, Canada, and the United States, in total encompassing 4,259 cases and 8,284 controls. Implementing a newly designed gene-based algorithm, we identified two loci apart from the region around APOE that achieved study-wide significance in combined samples, the strongest finding being for FRMD6 on chromosome 14q (P = 2.6 × 10(-14)) and a weaker signal for NARS2 that is immediately adjacent to GAB2 on chromosome 11q (P = 7.8 × 10(-9)). Ontology-based pathway analyses revealed significant enrichment of genes involved in glycosylation. Results suggest that gene-based approaches that accommodate allelic heterogeneity in GWAS can provide a complementary avenue for gene discovery and may help to explain a portion of the missing heritability not detectable with single nucleotide polymorphisms (SNPs) derived from marker-specific meta-analysis.
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- art (ämneskategori)
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- Av författaren/redakt...
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Hong, Mun-Gwan
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Reynolds, Chandr ...
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Feldman, Adina L
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Kallin, Mikael
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Lambert, Jean-Ch ...
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Amouyel, Philipp ...
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visa fler...
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Ingelsson, Erik, ...
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Pedersen, Nancy ...
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Prince, Jonathan ...
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visa färre...
- Artiklar i publikationen
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Human Mutation
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet