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FTO Genetic Variant...
FTO Genetic Variants and Risk of Obesity and Type 2 Diabetes : A Meta-Analysis of 28,394 Indians
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- Vasan, Senthil K. (författare)
- Karolinska Institutet
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Karpe, Fredrik (författare)
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- Gu, Harvest F. (författare)
- Karolinska Institutet
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- Brismar, Kerstin (författare)
- Karolinska Institutet
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Fall, Caroline H. (författare)
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- Ingelsson, Erik (författare)
- Uppsala universitet,Molekylär epidemiologi
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- Fall, Tove (författare)
- Uppsala universitet,Molekylär epidemiologi
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(creator_code:org_t)
- 2013-09-20
- 2014
- Engelska.
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Ingår i: Obesity. - : Wiley. - 1930-7381 .- 1930-739X. ; 22:3, s. 964-970
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- Objective: To investigate the magnitude of association of FTO variants with obesity, type 2 diabetes (T2DM), and related traits among Asian Indians. Methods: Random-effect meta-analysis was performed on pooled data from eight studies (n=28,394) for obesity and related traits and six studies (n=24,987) for assessment of T2DM risk in Indians where FTO variants were reported. Results: The minor A-allele of the FTO variant rs9939609 was associated with increased risk of obesity (OR 1.15, 95% CI 1.08-1.21, p=2.14 3 10 25), BMI (b=0.30 kg/m 2, 95% CI 0.21-0.38, p=4.78 3 10211) and other regional adiposity measurements [waist (b50.74 cm, 95% CI 0.49-0.99), HC (b=0.52, 95% CI 0.26-0.78), and waist-hip ratio (WHR) (b50.002, 95% CI 0.001-0.004)] in Indians (p = 0.001). An increased risk for T2DM (OR 1.11; 95% CI 1.04-1.19, p=0.002) was observed, which attenuated when adjusted for age, gender, and BMI (OR 1.09; 95% CI 1.02-1.16, p=0.01). Conclusions: Our study provides evidence of association between common FTO variant and obesity risk among Indians with comparable effect sizes as in Caucasians. The attenuation of FTO-T2DM risk on BMI adjustment reinforces that BMI does not fully account for the adiposity effects among Asian Indians who are more centrally obese.
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Obesity
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