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Inhibition of carci...
Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma
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- Salnikov, Alexei (författare)
- Lund University,Lunds universitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Heldin, Nils-Erik (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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Stuhr, Linda B. (författare)
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Wiig, Helge (författare)
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Gerber, Hanspeter (författare)
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Reed, Rolf K. (författare)
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- Rubin, Kristofer (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 119:12, s. 2795-2802
- Relaterad länk:
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https://onlinelibrar...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- The stroma of carcinomas shares several characteristics with inflamed tissues including a distorted vasculature, active angiogenesis and macrophage infiltration. In addition, the tumor interstitial fluid pressure (P-IF) of the stroma is pathologically elevated. We show here that bevacizumab [rhuMab vascular endothelial growth factor (VEGF), Avastin], a monoclonal antibody to VEGF, at a dose of 5 mg/kg modulated inflammation in KAT-4 xenograft human anaplastic thyroid carcinoma tissue. At this dose, bevacizumab reduced the density of macrophages, MHC class II antigen expression by macrophages and II-1 beta mRNA expression. Furthermore, bevacizumab lowered tumor extracellular fluid volume, plasma protein leakage from tumor vessels, the number of CD31positive structures and tumor P-IF. The tumor plasma volume and the number of alpha-smooth muscle actin-positive vessels, however, remained unchanged. Our data suggest that carcinoma cellderived VEGF either directly or indirectly participates in maintaining an inflammatory microenvironment in experimental KAT4 carcinoma. Furthermore, our data indicate that the reduction of inflammation resulting in reduced vascular permeability and decrease in the tumor extracellular fluid volume by bevacizurnab contributes to reduced tumor P-IF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- angiogenesis
- anaplastic thyroid carcinoma
- growth factors
- interstitial fluid pressure
- vasculature
- MEDICINE
- MEDICIN
- vasculature
- interstitial fluid pressure
- growth factors
- angiogenesis
- anaplastic thyroid carcinoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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