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Functional magnetic...
Functional magnetic resonance imaging in narcolepsy and the Kleine-Levin syndrome
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- Engström, Maria, 1958- (författare)
- Linköpings universitet,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Hallböök, Tove (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Pediat, Gothenburg, Sweden,Sahlgrenska Academy, University of Gothenburg, Sweden
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- Szakacs, Attila (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Pediat, Gothenburg, Sweden; Halmstad Cty Hosp, Dept Pediat, Halmstad, Sweden,Sahlgrenska Academy, University of Gothenburg. Sweden; Halmstad County Hospital, Sweden
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- Karlsson, Thomas (författare)
- Linköpings universitet,Handikappvetenskap,Filosofiska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Linnaeus Centre HEAD
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- Landtblom, Anne-Marie (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Uppsala universitet,Neurologi,Linkoping Univ, Ctr Med Image Sci & Visualizat CMIV, Linkoping, Sweden; Linkoping Univ, Dept Neurol, Dept Clin & Expt Med IKE, Linkoping, Sweden; Linkoping Univ, Dept Med & Hlth Sci, Dept Med Specialist, Motala, Sweden,Avdelningen för neurovetenskap,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Neurologiska kliniken,Medicinska specialistkliniken
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(creator_code:org_t)
- 2014-06-25
- 2014
- Engelska.
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Ingår i: Frontiers in Neurology. - Switzerland : Frontiers Media SA. - 1664-2295. ; 5
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Abstract
Ämnesord
Stäng
- This work aims at reviewing the present state of the art when it comes to understanding the pathophysiology of narcolepsy and the Kleine-Levin syndrome (KLS) from a neuroimaging point of view. This work also aims at discussing future perspectives of functional neuroimaging in these sleep disorders. We focus on functional magnetic resonance imaging (fMRI), which is a technique for in vivo measurements of brain activation in neuronal circuitries under healthy and pathological conditions. fMRI has significantly increased the knowledge on the affected neuronal circuitries in narcolepsy and the Kleine-Levin syndrome. It has been shown that narcolepsy is accompanied with disturbances of the emotional and the closely related reward systems. In the Kleine Levin syndrome, fMRI has identified hyperactivation of the thalamus as a potential biomarker that could be used in the diagnostic procedure. The fMRI findings in both narcolepsy and the Kleine-Levin syndrome are in line with previous structural and functional imaging studies. We conclude that fMRI in combination with multi-modal imaging can reveal important details about the pathophysiology in narcolepsy and the Kleine-Levin syndrome. In the future, fMRI possibly gives opportunities for diagnostic support and prediction of treatment response in individual patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- functional magnetic resonance imaging
- narcolepsy
- hypersomnia
- Kleine Levin syndrome
- sleep
- ascending arousal system
- hypothalamus
- thalamus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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