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Symmetric Dimethyla...
Symmetric Dimethylarginine as Predictor of Graft loss and All-Cause Mortality in Renal Transplant Recipients
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Pihlstrom, Hege (författare)
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Mjoen, Geir (författare)
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Dahle, Dag Olav (författare)
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Pilz, Stefan (författare)
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Midtvedt, Karsten (författare)
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Marz, Winfried (författare)
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Abedini, Sadollah (författare)
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Holme, Ingar (författare)
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- Fellström, Bengt (författare)
- Uppsala universitet,Njurmedicin
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Jardine, Alan (författare)
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Holdaas, Hallvard (författare)
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(creator_code:org_t)
- 2014
- 2014
- Engelska.
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Ingår i: Transplantation. - 0041-1337 .- 1534-6080. ; 98:11, s. 1219-1225
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: Elevated symmetric dimethylarginine (SDMA) has been shown to predict cardiovascular events and all cause mortality in diverse populations. The potential role of SDMA as a risk marker in renal transplant recipients (RTR) has not been investigated. METHODS: We analyzed SDMA in the placebo arm of the Assessment of Lescol in Renal Transplantation study, a randomized controlled trial of fluvastatin in RTR. Mean follow-up was 5.1 years. Patients were grouped into quartiles based on SDMA levels at study inclusion. Relationships between SDMA and traditional risk factors for graft function and all-cause mortality were analyzed in 925 RTR using univariate and multivariate survival analyses. RESULTS: In univariate analysis, SDMA was significantly associated with renal graft loss, all-cause death, and major cardiovascular events. After adjustment for established risk factors including estimated glomerular filtration rate, an elevated SDMA-level (4th quartile, >1.38 mumol/L) was associated with renal graft loss; hazard ratio (HR), 5.51; 95% confidence interval (CI), 1.95-15.57; P=0.001, compared to the 1st quartile. Similarly, SDMA in the 4th quartile was independently associated with all-cause mortality (HR, 4.56; 95% CI, 2.15-9.71; P<0.001), and there was a strong borderline significant trend for an association with cardiovascular mortality (HR, 2.86; 95% CI, 0.99-8.21; P=0.051). CONCLUSION: In stable RTR, an elevated SDMA level is independently associated with increased risk of all-cause mortality and renal graft loss.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Pihlstrom, Hege
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Mjoen, Geir
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Dahle, Dag Olav
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Pilz, Stefan
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Midtvedt, Karste ...
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Marz, Winfried
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visa fler...
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Abedini, Sadolla ...
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Holme, Ingar
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Fellström, Bengt
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Jardine, Alan
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Holdaas, Hallvar ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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Transplantation
- Av lärosätet
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Uppsala universitet