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Penicillium nalgiov...
Penicillium nalgiovense Laxa isolated from Antarctica is a new source of the antifungal metabolite amphotericin B
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- Svahn, Stefan, 1977- (författare)
- Uppsala universitet,Avdelningen för farmakognosi,Uppsala Universitet
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- Chryssanthou, Erja (författare)
- Karolinska Institutet
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Olsen, Björn (författare)
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- Bohlin, Lars (författare)
- Uppsala universitet,Avdelningen för farmakognosi
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- Göransson, Ulf (författare)
- Uppsala universitet,Avdelningen för farmakognosi
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(creator_code:org_t)
- 2015-01-17
- 2015
- Engelska.
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Ingår i: Fungal biology and biothechnology. - : Springer Science and Business Media LLC. - 2054-3085. ; 2:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: The need for new antibiotic drugs increases as pathogenic microorganisms continue to develop resistance against current antibiotics. We obtained samples from Antarctica as part of a search for new antimicrobial metabolites derived from filamentous fungi. This terrestrial environment in the South Pole is hostile and extreme due to a sparsely populated food web, low temperatures, and insufficient liquid water availability. We hypothesize that this environment could cause the development of fungal defense or survival mechanisms not found elsewhere.Results: We isolated a strain of Penicillium nalgiovense Laxa from a soil sample obtained from an abandoned penguin’s nest. Amphotericin B was the only metabolite secreted from P. nalgiovense Laxa with noticeable antimicrobial activity,with minimum inhibitory concentration of 0.125 µg/mL against Candida albicans. This is the first time that amphotericin B has been isolated from an organism other than the bacterium Streptomyces nodosus. In terms of amphotericin B production, cultures on solid medium proved to be a more reliable and favorable choice compared to a liquid.Conclusions: These results encourage further investigation of the many unexplored sampling sites characterized by extreme conditions, and confirm filamentous fungi as potential sources of metabolites with antimicrobial activity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- Amphotericin B
- Penicillium nalgiovense Laxa
- Antarctica
- Pharmacognosy
- Farmakognosi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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