Teratogenicity by the hERG potassium channel blocking drug almokalant : use of hypoxia marker gives evidence for a hypoxia-related mechanism mediated via embryonic arrhythmia.

Nyckelord

Abnormalities; Drug-Induced

Administration; Oral

Animals

Arrhythmia/*chemically induced/embryology

Cation Transport Proteins

Dose-Response Relationship; Drug

Ether-A-Go-Go Potassium Channels

Female

Fetal Hypoxia/chemically induced/physiopathology

Image Processing; Computer-Assisted

Injections; Intravenous

Nitroimidazoles/administration & dosage/diagnostic use

Potassium Channel Blockers/administration & dosage/*toxicity

Potassium Channels/*drug effects/metabolism

Potassium Channels; Voltage-Gated

Pregnancy

Propanolamines/administration & dosage/*toxicity

Rats

Rats; Sprague-Dawley

Teratogens/*toxicity

Videotape Recording

Publikations- och innehållstyp

vet (ämneskategori)

art (ämneskategori)