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Differential cellul...
Differential cellular responses in healthy mice and in mice with established airway inflammation when exposed to hematite nanoparticles
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- Gustafsson, Åsa (författare)
- Umeå universitet,Lungmedicin,Swedish Def Res Agcy, Div CBRN Def & Secur, SE-90182 Umea, Sweden.;Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden.
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- Bergström, Ulrika (författare)
- Uppsala universitet,Miljötoxikologi,Swedish Def Res Agcy, Div CBRN Def & Secur, SE-90182 Umea, Sweden.
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- Agren, Lina (författare)
- Swedish Def Res Agcy, Div CBRN Def & Secur, SE-90182 Umea, Sweden.
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- Österlund, Lars (författare)
- Uppsala universitet,Fasta tillståndets fysik
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- Sandström, Thomas (författare)
- Umeå universitet,Lungmedicin,Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden.
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- Bucht, Anders (författare)
- Umeå universitet,Lungmedicin,Swedish Def Res Agcy, Div CBRN Def & Secur, SE-90182 Umea, Sweden.;Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden.
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
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Ingår i: Toxicology and Applied Pharmacology. - : Elsevier BV. - 0041-008X .- 1096-0333. ; 288:1, s. 1-11
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The aim of this study was to investigate the inflammatory and immunological responses in airways and lung-draining lymph nodes (LDLNs), following lung exposure to iron oxide (hematite) nanoparticles (NPs). The responses to the hematite NPs were evaluated in both healthy non-sensitized mice, and in sensitized mice with an established allergic airway disease. The mice were exposed intratracheally to either hematite NPs or to vehicle (PBS) and the cellular responses were evaluated on days 1, 2, and 7, post-exposure. Exposure to hematite NPs increased the numbers of neutrophils, eosinophils, and lymphocytes in the airways of non-sensitized mice on days 1 and 2 post-exposure; at these time points the number of lymphocytes was also elevated in the LDLNs. In contrast, exposing sensitized mice to hematite NPs induced a rapid and unspecific cellular reduction in the alveolar space on day 1 post-exposure; a similar decrease of lymphocytes was also observed in the LDLN. The results indicate that cells in the airways and in the LDLN of individuals with established airway inflammation undergo cell death when exposed to hematite NPs. A possible explanation for this toxic response is the extensive generation of reactive oxygen species (ROS) in the pro-oxidative environment of inflamed airways. This study demonstrates how sensitized and non-sensitized mice respond differently to hematite NP exposure, and it highlights the importance of including individuals with respiratory disorders when evaluating health effects of inhaled nanomaterials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Iron oxide
- alpha-Fe2O3
- Hematite
- Inflammation
- Reactive oxygen species
- Nanoparticles
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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