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Molecular organizat...
Molecular organization and fine structure of the human tectorial membrane : is it replenished?
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- Hayashi, Hisamitsu (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar,Gifu Univ, Grad Sch Med, Dept Otolaryngol, Gifu, Gifu 5011194, Japan
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- Schrott-Fischer, Annelies (författare)
- Med Univ Innsbruck, Dept Otolaryngol, A-6020 Innsbruck, Austria
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- Glueckert, Rudolf (författare)
- Med Univ Innsbruck, Dept Otolaryngol, A-6020 Innsbruck, Austria
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- Liu, Wei (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Salvenmoser, Willi (författare)
- Univ Innsbruck, Inst Zool, A-6020 Innsbruck, Austria
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- Santi, Peter (författare)
- Univ Minnesota, Dept Otolaryngol, Minneapolis, MN 55455 USA
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- Rask-Andersen, Helge (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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(creator_code:org_t)
- 2015-06-18
- 2015
- Engelska.
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Ingår i: Cell and Tissue Research. - : Springer Science and Business Media LLC. - 0302-766X .- 1432-0878. ; 362:3, s. 513-527
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Auditory sensitivity and frequency resolution depend on the physical properties of the basilar membrane in combination with outer hair cell-based amplification in the cochlea. The physiological role of the tectorial membrane (TM) in hair cell transduction has been controversial for decades. New insights into the TM structure and function have been gained from studies of targeted gene disruption. Several missense mutations in genes regulating the human TM structure have been described with phenotypic expressions. Here, we portray the remarkable gradient structure and molecular organization of the human TM. Ultrastructural analysis and confocal immunohistochemistry were performed in freshly fixed human cochleae obtained during surgery. Based on these findings and recent literature, we discuss the role of human TMs in hair cell activation. Moreover, the outcome proposes that the α-tectorin-positive amorphous layer of the human TM is replenished and partly undergoes regeneration during life.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Tectorial membrane; Human; Electron microscopy; alpha-tectorin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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