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Prediction of AD de...
Prediction of AD dementia by biomarkers following the NIA-AA and IWG diagnostic criteria in MCI patients from three European memory clinics
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- Prestia, Annapaola (författare)
- IRCCS, Ctr San Giovanni Dio Fatebenefratelli, Lab Epidemiol & Neuroimaging, Brescia, Italy.
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- Caroli, Anna (författare)
- IRCCS, Mario Negri Inst Pharmacol Res, Dept Biomed Engn, Med Imaging Unit, Bergamo, Italy.
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- Wade, Sara K. (författare)
- Univ Cambridge, Dept Engn, Cambridge CB2 1PZ, England.;Bocconi Univ, Dept Decis Sci, Milan, Italy.
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- van der Flier, Wiesjie M. (författare)
- Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, Dept Neurol, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands.
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- Ossenkoppele, Rik (författare)
- Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, Dept Neurol, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, Dept Radiol & Nucl Med & PET Res, Amsterdam, Netherlands.
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- Van Berckel, Bart (författare)
- Vrije Univ Amsterdam Med Ctr, Dept Radiol & Nucl Med & PET Res, Amsterdam, Netherlands.
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- Barkhof, Frederik (författare)
- Vrije Univ Amsterdam Med Ctr, Dept Radiol & Nucl Med & PET Res, Amsterdam, Netherlands.
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- Teunissen, Charlotte E. (författare)
- Vrije Univ Amsterdam Med Ctr, Dept Clin Chem, Amsterdam, Netherlands.
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- Wall, Anders (författare)
- Uppsala universitet,Radiologi
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- Carter, Stephen F. (författare)
- Karolinska Institutet,Karolinska Inst, Alzheimer Neurobiol Ctr, Stockholm, Sweden.
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- Scholl, Michael (författare)
- Karolinska Inst, Alzheimer Neurobiol Ctr, Stockholm, Sweden.
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- Choo, Il Han (författare)
- Karolinska Inst, Alzheimer Neurobiol Ctr, Stockholm, Sweden.;Chosun Univ, Sch Med, Dept Neuropsychiat, Gwangju, South Korea.
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- Nordberg, Agneta (författare)
- Karolinska Institutet,Karolinska Inst, Alzheimer Neurobiol Ctr, Stockholm, Sweden.;Karolinska Univ, Huddinge Hosp, Dept Geriatr Med, Stockholm, Sweden.
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- Scheltens, Philip (författare)
- Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, Dept Neurol, Amsterdam, Netherlands.
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- Frisoni, Giovanni B. (författare)
- IRCCS, Ctr San Giovanni Dio Fatebenefratelli, Lab Epidemiol & Neuroimaging, Brescia, Italy.;Univ Hosp Geneva, Dept Internal Med, Geneva, Switzerland.;Univ Hosp Geneva, Dept Psychiat, Geneva, Switzerland.;Univ Geneva, Geneva, Switzerland.
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IRCCS, Ctr San Giovanni Dio Fatebenefratelli, Lab Epidemiol & Neuroimaging, Brescia, Italy IRCCS, Mario Negri Inst Pharmacol Res, Dept Biomed Engn, Med Imaging Unit, Bergamo, Italy. (creator_code:org_t)
- 2015-01-31
- 2015
- Engelska.
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 11:10, s. 1191-1201
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: Proposed diagnostic criteria (international working group and National Institute on Aging and Alzheimer's Association) for Alzheimer's disease (AD) include markers of amyloidosis (abnormal cerebrospinal fluid [CSF] amyloid beta [A beta]42) and neurodegeneration (hippocampal atrophy, temporo-parietal hypometabolism on [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and abnormal CSF tau). We aim to compare the accuracy of these biomarkers, individually and in combination, in predicting AD among mild cognitive impairment (MCI) patients. Methods: In 73 MCI patients, followed to ascertain AD progression, markers were measured. Sensitivity and specificity, positive (LR+) and negative (LR-) likelihood ratios, and crude and adjusted hazard ratios were computed. Results: Twenty-nine MCI patients progressed and 44 remained stable. Positivity to any marker achieved the lowest LR- (0.0), whereas the combination A beta 42 plus FDG-PET achieved the highest LR+ (6.45). In a survival analysis, positivity to any marker was associated with 100% conversion rate, whereas negativity to all markers was associated with 100% stability. Discussion: The best criteria combined amyloidosis and neurodegeneration biomarkers, whereas the individual biomarker with the best performance was FDG-PET.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer's disease
- MCI
- MRI
- PET
- Diagnostic criteria
- Diagnostic accuracy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Prestia, Annapao ...
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Caroli, Anna
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Wade, Sara K.
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van der Flier, W ...
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Ossenkoppele, Ri ...
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Van Berckel, Bar ...
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Barkhof, Frederi ...
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Teunissen, Charl ...
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Wall, Anders
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Carter, Stephen ...
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Scholl, Michael
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Choo, Il Han
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Nordberg, Agneta
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Scheltens, Phili ...
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Frisoni, Giovann ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Alzheimer's & De ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet