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Serum lactate dehyd...
Serum lactate dehydrogenase and survival following cancer diagnosis
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- Wulaningsih, Wahyu (författare)
- Kings Coll London, Guys Hosp, Canc Epidemiol Grp, Div Canc Studies,Res Oncol, London SE1 9RT, England.
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- Holmberg, Lars (författare)
- Uppsala universitet,Endokrinkirurgi,Kings Coll London, Guys Hosp, Canc Epidemiol Grp, Div Canc Studies,Res Oncol, London SE1 9RT, England.;Reg Canc Ctr, S-75185 Uppsala, Sweden.
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- Garmo, Hans (författare)
- Kings Coll London, Guys Hosp, Canc Epidemiol Grp, Div Canc Studies,Res Oncol, London SE1 9RT, England.;Reg Canc Ctr, S-75185 Uppsala, Sweden.
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- Malmstrom, Hakan (författare)
- Karolinska Institutet
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- Lambe, Mats (författare)
- Karolinska Institutet
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- Hammar, Niklas (författare)
- Karolinska Institutet
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- Walldius, Goran (författare)
- Karolinska Institutet
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- Jungner, Ingmar (författare)
- Karolinska Institutet
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- Ng, Tony (författare)
- Kings Coll London, Randall Div, Richard Dimbleby Dept Canc Res, London SE1 1UL, England.;Kings Coll London, Div Canc Studies, London SE1 1UL, England.
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- Van Hemelrijck, Mieke (författare)
- Kings Coll London, Guys Hosp, Canc Epidemiol Grp, Div Canc Studies,Res Oncol, London SE1 9RT, England.;Karolinska Inst, Inst Environm Med, Dept Epidemiol, S-17177 Stockholm, Sweden.
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Kings Coll London, Guys Hosp, Canc Epidemiol Grp, Div Canc Studies,Res Oncol, London SE1 9RT, England Endokrinkirurgi (creator_code:org_t)
- 2015-10-15
- 2015
- Engelska.
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 113:9, s. 1389-1396
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: There is evidence that high level of serum lactate dehydrogenase (LDH) is associated with poorer overall survival in several malignancies, but its link to cancer-specific survival is unclear. Methods: A total of 7895 individuals diagnosed with cancer between 1986 and 1999 were selected for this study. Multivariable Cox proportional hazards regression was used to assess overall and cancer-specific death by the z-score and clinical categories of serum LDH prospectively collected within 3 years before diagnosis. Site-specific analysis was performed for major cancers. Analysis was repeated by different lag times between LDH measurements and diagnosis. Results: At the end of follow-up, 5799 participants were deceased. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall and cancer-specific death in the multivariable model were 1.43 (1.31-1.56) and 1.46 (1.32-1.61), respectively, for high compared with low prediagnostic LDH. Site-specific analysis showed high LDH to correlate with an increased risk of death from prostate, pulmonary, colorectal, gastro-oesophageal, gynaecological and haematological cancers. Serum LDH assessed within intervals closer to diagnosis was more strongly associated with overall and cancer-specific death. Conclusions: Our findings demonstrated an inverse association of baseline serum LDH with cancer-specific survival, corroborating its role in cancer progression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- LDH
- the Warburg effect
- survival
- prospective study
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Wulaningsih, Wah ...
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Holmberg, Lars
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Garmo, Hans
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Malmstrom, Hakan
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Lambe, Mats
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Hammar, Niklas
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visa fler...
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Walldius, Goran
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Jungner, Ingmar
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Ng, Tony
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Van Hemelrijck, ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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British Journal ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet