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Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells
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- Vogel, Stephanie (författare)
- TWINCORE, Ctr Expt & Clin Infect Res, Inst Expt Infect Res, D-30625 Hannover, Germany.
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- Grabski, Elena (författare)
- TWINCORE, Ctr Expt & Clin Infect Res, Inst Expt Infect Res, D-30625 Hannover, Germany.
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- Buschjaeger, Daniela (författare)
- TWINCORE, Ctr Expt & Clin Infect Res, Inst Expt Infect Res, D-30625 Hannover, Germany.
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- Wang, Junxi (författare)
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- TWINCORE, Ctr Expt & Clin Infect Res, Inst Expt Infect Res, D-30625 Hannover, Germany Ostfalia Univ Appl Sci, Dept Comp Sci, D-38302 Wolfenbuttel, Germany.;Helmholtz Ctr Infect Res, Biostat, D-38124 Braunschweig, Germany. (creator_code:org_t)
- 2015-12-16
- 2015
- Engelska.
- Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Treatment of PBMC with the CD4-specific mAb BT-061 induces CD4 down-modulation of T cells. Here we report that addition of BT-061 to purified T cells did not confer this effect, whereas incubation of T cells in BT-061 coated wells restored CD4 down-modulation. These results implied that Fc gamma receptor mediated cell-cell interactions played a role. In consistence with this hypothesis PBMC depleted of CD64(+) monocytes did not confer CD4 down-modulation of BT-061 decorated T cells. Strikingly, CD4 down-modulation was observed in BT-061 treated synovial fluid punctuated from patients' inflamed joints that comprised enhanced numbers of CD64(+) cells. In contrast, in a circulating whole blood system injection of BT-061 did not induce CD4 down-modulation, due to CD64 saturation by serum IgG. Similarly, tonsil derived mononuclear cells devoid of CD64(+) cells did not show CD4 down-modulation, whereas addition of blood derived monocytes restored the effect. Thus, the interaction of BT-061 decorated T cells with CD64(+) cells is needed for CD4 down-modulation, implying that in patients BT-061 would primarily induce CD4 down-modulation at inflammatory sites. These results highlight the need not only to examine the interaction of a given mAb with single Fc gamma R, but also the immunological environment that is appropriate to support such interactions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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