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Predictive Value of...
Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia
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Zeisler, Harald (författare)
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Llurba, Elisa (författare)
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Chantraine, Frederic (författare)
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visa fler...
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Vatish, Manu (författare)
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Staff, Anne Cathrine (författare)
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- Sennström, Maria (författare)
- Karolinska Institutet
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- Olovsson, Matts (författare)
- Uppsala universitet,Obstetrik & gynekologi
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Brennecke, Shaun P (författare)
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Stepan, Holger (författare)
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Allegranza, Deirdre (författare)
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Dilba, Peter (författare)
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Schoedl, Maria (författare)
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Hund, Martin (författare)
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Verlohren, Stefan (författare)
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 374:1, s. 13-22
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- BACKGROUND: The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia, but its predictive value in women with suspected preeclampsia is unclear.METHODS: We performed a prospective, multicenter, observational study to derive and validate a ratio of serum sFlt-1 to PlGF that would be predictive of the absence or presence of preeclampsia in the short term in women with singleton pregnancies in whom preeclampsia was suspected (24 weeks 0 days to 36 weeks 6 days of gestation). Primary objectives were to assess whether low sFlt-1:PlGF ratios (at or below a derived cutoff) predict the absence of preeclampsia within 1 week after the first visit and whether high ratios (above the cutoff) predict the presence of preeclampsia within 4 weeks.RESULTS: In the development cohort (500 women), we identified an sFlt-1:PlGF ratio cutoff of 38 as having important predictive value. In a subsequent validation study among an additional 550 women, an sFlt-1:PlGF ratio of 38 or lower had a negative predictive value (i.e., no preeclampsia in the subsequent week) of 99.3% (95% confidence interval [CI], 97.9 to 99.9), with 80.0% sensitivity (95% CI, 51.9 to 95.7) and 78.3% specificity (95% CI, 74.6 to 81.7). The positive predictive value of an sFlt-1:PlGF ratio above 38 for a diagnosis of preeclampsia within 4 weeks was 36.7% (95% CI, 28.4 to 45.7), with 66.2% sensitivity (95% CI, 54.0 to 77.0) and 83.1% specificity (95% CI, 79.4 to 86.3).CONCLUSIONS: An sFlt-1:PlGF ratio of 38 or lower can be used to predict the short-term absence of preeclampsia in women in whom the syndrome is suspected clinically. (Funded by Roche Diagnostics.).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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- Av författaren/redakt...
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Zeisler, Harald
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Llurba, Elisa
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Chantraine, Fred ...
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Vatish, Manu
-
Staff, Anne Cath ...
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Sennström, Maria
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visa fler...
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Olovsson, Matts
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Brennecke, Shaun ...
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Stepan, Holger
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Allegranza, Deir ...
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Dilba, Peter
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Schoedl, Maria
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Hund, Martin
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Verlohren, Stefa ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
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New England Jour ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet