Selective cleavage of the O-6-diphenylcarbamoyl group from sugar-modified guanosines for incorporation into oligo-RNA

• A facile conversion of 2',3',5'-O-tri-(Bz, Tol or Ac)-N-2-(Ac or iBu)-O-6-DPC-guanosine to N-2-(Ac or iBu)guanosine has been achieved in 89-98% yield by short treatment with 90% aqueous TFA for smooth cleavage of the DPC group followed by treatment with s

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EFFICIENT SYNTHESIS; ANALOGS; DODECARIBONUCLEOTIDE; WINDOW; BLOCKS; DNA

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