Determination of the group electronegativity of CF3 group in 3 '-O-CF3-thymidine by H-1-NMR

• The interplay of enthalpy of the gauche effect (Delta H degrees(GE)) Of the [X3'-C3'-C4'-O4'] fragment in various 3'-substituted (X) 2',3'-dideoxythymidine derivatives 1 - 7 and the inherent anomeric effect drives the two-state North reversible arrow Sout

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NMR COUPLING-CONSTANTS; PSEUDOROTATIONAL EQUILIBRIUM; CONFORMATIONAL-ANALYSIS; PENTOFURANOSE MOIETY; SUGAR CONFORMATION; C-NUCLEOSIDES; SUBSTITUENT ELECTRONEGATIVITIES; FURANOSE RING; PROTON; GAUCHE

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