How kinetically accessible is an RNA target for hybridization with an antisense oligo? A lesson from an RNA target which is as small as a 20mer

• A 20 mer RNA (1), characterized as a duplex with two A.A mismatch basepairs and four tandem G.U wobble basepairs, was targeted at the first A.A internal loop by nonameric 5'-Polyarene DNA-conjugates. For comparison, its DNA counterpart (10), which was fou

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antisense target; polyarenes; DNA conjugates; NUCLEAR-MAGNETIC-RESONANCE; CIRCULAR-DICHROISM; MISMATCHES; DNA; STABILITY; SEQUENCE; NMR; OLIGONUCLEOTIDES; THERMODYNAMICS; TRANSITIONS

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