Synthesis of partially-deuterated 2 '-deoxyribonucleoside blocks and their incorporation into an oligo-DNA for simplification of overcrowding and selective enhancement of resolution and sensitivity in the H-1-NMR spectra

• The chemical synthesis of appropriately protected partially-deuterated 2'((R) under bar/(S) under bar), 3',5'((R) under bar/(S) under bar)-H-2(3)-2'-deoxyribonucleoside blocks [similar to 43 atom % H-2 at C5'((R) under bar), similar to 57 atom % H-2 at C5

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ACID RELATED-COMPOUNDS; NUCLEAR-MAGNETIC-RESONANCE; NMR-WINDOW; METHYLENE PROTONS; GENERAL-SYNTHESIS; CHEMICAL-SHIFTS; RNA; CONFORMATION; RIBONUCLEOSIDES; DERIVATIVES

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