Partially-deuterated oligo-DNA reduces overcrowding, enhances resolution and sensitivity and provide improved NMR constraints for structure elucidation of oligo-DNA

• The usefulness of the "NMR-window III" approach (see ref. 2e) has been demonstrated through the use of the deuterio isotopomeric 12mer oligo-DNA duplex obtained from protected partially deuterated 2'((R) under bar/(S) under bar), 3', 5'((R) under bar/(S)

Nyckelord

COUPLING-CONSTANTS; ENZYMATIC-SYNTHESIS; H-1-NMR WINDOW; HETERONUCLEAR NMR; RNA; PROTONS; OLIGONUCLEOTIDES; NUCLEOSIDES; DERIVATIVES; ASSIGNMENT

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