NMR conformation of (-)-beta-D-aristeromycin and its 2 '-deoxy and 3 '-deoxy counterparts in aqueous solution

• The solution conformations of aristeromycin (1), 2'-deoxyaristeromycin (2), and 3'-deoxyaristeromycin (3) have been determined from an integrated analysis of X-ray (for 1 only), NMR data (i.e., (3)J(HH) coupling constants), and ab initio calculations. One

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HIV AIDS VIRUS; PSEUDOROTATIONAL EQUILIBRIUM; PENTOFURANOSE MOIETY; COUPLING-CONSTANTS; CRYSTAL-STRUCTURE; SUBSTITUENT ELECTRONEGATIVITIES; CARBOCYCLIC THYMIDINE; REVERSE-TRANSCRIPTASE; H-1-NMR SPECTROSCOPY; MOLECULAR-STRUCTURE

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