Determination of the solution conformation of a non-uniformly deuterium labelled (Uppsala 'NMR-window') 21mer RNA hairpin by NMR spectroscopy and computational methods.

• The conformation of a 21mer RNA hairpin, 5'-r(AGCCCGCCUAAUGAGCGGGCU)-3, was determined by NMR spectroscopy and computer calculations. The 'Uppsala NMR-window' approach was used to overcome the problem of spectral overlap.

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TIME-AVERAGED RESTRAINTS; MOLECULAR-DYNAMICS; H-1-NMR WINDOW; OLIGO-DNA; SIMPLIFY; RESIDUES; PROTONS; DUPLEX; H-1

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