THE SOLUTION STRUCTURE OF A 3'-PHENAZINIUM (PZN) TETHERED DNA-RNA DUPLEX WITH A DANGLING ADENOSINE - R(5'GAUUGAA3')-D(5'TCAATC3'-PZN)

• The 3'-Pzn group tethered to an oligo-DNA stabilizes a DNA-RNA hybrid duplex structure by 13 degrees C compared to the natural counterpart. This report constitutes the first full study of the conformational features of a hybrid DNA-RNA duplex, which has b

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DOUBLE-HELICAL DNA; MOLECULAR MECHANICS CALCULATIONS; RELAXATION MATRIX ANALYSIS; COUPLING-CONSTANTS; COMPLEX-FORMATION; AQUEOUS-SOLUTION; HYBRID DUPLEXES; NMR; SEQUENCE; SPECTROSCOPY

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