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Increased plasma UC...
Increased plasma UCH-L1 after aneurysmal subarachnoid hemorrhage is associated with unfavorable neurological outcome
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- Kiiski, Heikki (författare)
- Tampere Univ Hosp, Dept Intens Care, Crit Care Med Res Grp, Tampere, Finland.;Univ Tampere, NeuroGrp, BioMediTech, FIN-33101 Tampere, Finland.
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- Tenhunen, Jyrki (författare)
- Uppsala universitet,Anestesiologi och intensivvård,Tampere Univ Hosp, Dept Intens Care, Crit Care Med Res Grp, Tampere, Finland.
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- Ala-Peijari, Marika (författare)
- Tampere Univ Hosp, Dept Intens Care, Crit Care Med Res Grp, Tampere, Finland.
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- Huhtala, Heini (författare)
- Univ Tampere, Sch Hlth Sci, FIN-33101 Tampere, Finland.
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- Hamalainen, Mari (författare)
- Univ Tampere, Tampere Univ Hosp, Sch Med, Immunopharmacol Res Grp, FIN-33101 Tampere, Finland.
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- Langsjo, Jaakko (författare)
- Tampere Univ Hosp, Dept Intens Care, Crit Care Med Res Grp, Tampere, Finland.
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- Moilanen, Eeva (författare)
- Univ Tampere, Tampere Univ Hosp, Sch Med, Immunopharmacol Res Grp, FIN-33101 Tampere, Finland.
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- Narkilahti, Susanna (författare)
- Univ Tampere, NeuroGrp, BioMediTech, FIN-33101 Tampere, Finland.
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- Ohman, Juha (författare)
- Tampere Univ Hosp, Dept Neurosci & Rehabil, Tampere, Finland.
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- Peltola, Jukka (författare)
- Tampere Univ Hosp, Dept Neurosci & Rehabil, Tampere, Finland.
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Tampere Univ Hosp, Dept Intens Care, Crit Care Med Res Grp, Tampere, Finland;Univ Tampere, NeuroGrp, BioMediTech, FIN-33101 Tampere, Finland. Anestesiologi och intensivvård (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Journal of the Neurological Sciences. - : Elsevier BV. - 0022-510X .- 1878-5883. ; 361, s. 144-149
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Aneurysmal subarachnoid hemorrhage (aSAH) is a common cause of long-term disability and death. After primary hemorrhage, secondary brain injury is the main cause of mortality and morbidity. Despite extensive research, reliable prognostic biomarkers are lacking. We measured ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) levels in aSAH patients to evaluate its prognostic potential. This is the first time that plasma UCH-L1 has been studied as a potential prognostic biomarker in patients with aSAH. Methods: In this prospective population-based study, UCH-L1 levels were measured in aSAH patients (n = 47) for up to five days. UCH-L1 was measured at 0, 12 and 24 h after the admission to the intensive care unit (ICU) and daily thereafter until the patient was transferred from the ICU. Only patients whose UCH-L1 was measured within 24 h from aSAH were included in the study. The patients' neurological outcome was evaluated with the modified Rankin Scale (mRS) at six months after aSAH. Results: UCH-L1 levels during the first 24 h after aSAH were not significantly different between the groups with favorable (mRS 0-2) and unfavorable (mRS 3-6) neurological outcome. In 22 patients, UCH-L1 levels were obtained for up to five days. In this subgroup, UCH-L1 measured at day five showed significant elevation from baseline levels in patients with unfavorable outcome (p = 0.026). Elevated UCH-L1 levels at day five were higher in patients with unfavorable outcome than in patients with favorable outcome (p = 0.001). Conclusions: Elevated UCH-L1 levels during the five-day follow-up were associated with unfavorable neurological outcome. Repetitive measurements of UCH-L1 concentrations with an emphasis on change relative to the individual baseline could be the optimal approach for future clinical studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Aneurysmal subarachnoid hemorrhage
- Biomarkers
- UCH-L1
- Neurological outcome
- Secondary brain injury
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kiiski, Heikki
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Tenhunen, Jyrki
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Ala-Peijari, Mar ...
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Huhtala, Heini
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Hamalainen, Mari
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Langsjo, Jaakko
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visa fler...
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Moilanen, Eeva
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Narkilahti, Susa ...
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Ohman, Juha
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Peltola, Jukka
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Journal of the N ...
- Av lärosätet
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Uppsala universitet