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Extension of diffus...
Extension of diffuse low-grade gliomas beyond radiological borders as shown by the coregistration of histopathological and magnetic resonance imaging data
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- Zetterling, Maria (författare)
- Uppsala universitet,Neurokirurgi,Uppsala University, Sweden; Uppsala University Hospital, Sweden
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- Roodakker, Kenney Roy, 1989- (författare)
- Uppsala universitet,Neurologi,Uppsala University, Sweden
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- Berntsson, Shala Ghaderi (författare)
- Uppsala universitet,Neurologi,Uppsala University, Sweden; University of Uppsala Hospital, Sweden
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- Edqvist, Per-Henrik D (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden
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- Latini, Francesco (författare)
- Uppsala universitet,Neurokirurgi,Uppsala University, Sweden
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- Landtblom, Anne-Marie (författare)
- Linköpings universitet,Uppsala universitet,Neurologi,Linköping Univ, Ctr Med Image Sci & Visualizat, Linköping, Sweden,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Neurologiska kliniken i Linköping,Uppsala University, Sweden; University of Uppsala Hospital, Sweden
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- Pontén, Fredrik (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi,Uppsala University, Sweden
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- Alafuzoff, Irina (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Uppsala University, Sweden; University of Uppsala Hospital, Sweden
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- Larsson, Elna-Marie (författare)
- Uppsala universitet,Radiologi,Uppsala University, Sweden; University of Uppsala Hospital, Sweden
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- Smits, Anja (författare)
- Uppsala universitet,Neurologi,Danish Epilepsy Ctr, Dianalund, Denmark,Uppsala University, Sweden; University of Uppsala Hospital, Sweden; Danish Epilepsy Centre, Denmark
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(creator_code:org_t)
- AMER ASSOC NEUROLOGICAL SURGEONS, 2016
- 2016
- Engelska.
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Ingår i: Journal of Neurosurgery. - : AMER ASSOC NEUROLOGICAL SURGEONS. - 0022-3085 .- 1933-0693. ; 125:5, s. 1155-1166
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Magnetic resonance imaging tends to underestimate the extent of diffuse low-grade gliomas (DLGGs). With the aim of studying the presence of tumor cells outside the radiological border, the authors developed a method of correlating MRI findings with histological data in patients with suspected DLGGs in whom en bloc resections were performed.Methods: Five patients with suspected DLGG suitable for en bloc resection were recruited from an ongoing prospective study. Sections of the entire tumor were immunostained with antibodies against mutated IDH1 protein (IDH1-R132H). Magnetic resonance images were coregistered with corresponding IDH1 images. The growth pattern of tumor cells in white and gray matter was assessed in comparison with signal changes on corresponding MRI slices.Results: Neuropathological assessment revealed DLGG in 4 patients and progression to WHO Grade III glioma in 1 patient. The tumor core consisted of a high density of IDH1-R132H–positive tumor cells and was located in both gray and white matter. Tumor cells infiltrated along the peripheral fibers of the white matter tracts. In all cases, tumor cells were found outside the radiological tumor border delineated on T2-FLAIR MRI sequences.Conclusions: The authors present a new method for the coregistration of histological and radiological characteristics of en bloc–removed infiltrative brain tumors that discloses tumor invasion at the radiological tumor borders. This technique can be applied to evaluate the sensitivity of alternative imaging methods to detect scattered tumor cells at tumor borders. Accurate methods for detection of infiltrative tumor cells will improve the possibility of performing radical tumor resection. In future studies, the method could also be used for in vivo studies of tumor invasion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- diffuse low-grade glioma
- magnetic resonance imaging
- tumor border
- tumor cell infiltration
- oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Zetterling, Mari ...
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Roodakker, Kenne ...
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Berntsson, Shala ...
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Edqvist, Per-Hen ...
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Latini, Francesc ...
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Landtblom, Anne- ...
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visa fler...
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Pontén, Fredrik
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Alafuzoff, Irina
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Larsson, Elna-Ma ...
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Smits, Anja
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
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Journal of Neuro ...
- Av lärosätet
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Uppsala universitet
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Linköpings universitet