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Investigating DNA R...
Investigating DNA Radiation Damage Using X-Ray Absorption Spectroscopy
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- Czapla-Masztafiak, Joanna (author)
- Paul Scherrer Inst, Villigen, Switzerland.;Polish Acad Sci, Inst Nucl Phys, Krakow, Poland.
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- Szlachetko, Jakub (author)
- Paul Scherrer Inst, Villigen, Switzerland.;Jan Kochanowski Univ Humanities & Sci, Inst Phys, Kielce, Poland.
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- Milne, Christopher J. (author)
- Paul Scherrer Inst, Villigen, Switzerland.
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Lipiec, Ewelina (author)
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- Sa, Jacinto (author)
- Uppsala universitet,Fysikalisk kemi,Polish Acad Sci, Inst Phys Chem, Warsaw, Poland.
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- Penfold, Thomas J. (author)
- Newcastle Univ, Dept Chem, Bedson Bldg, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
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- Huthwelker, Thomas (author)
- Paul Scherrer Inst, Villigen, Switzerland.
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- Borca, Camelia (author)
- Paul Scherrer Inst, Villigen, Switzerland.
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- Abela, Rafael (author)
- Paul Scherrer Inst, Villigen, Switzerland.
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- Kwiatek, Wojciech M. (author)
- Polish Acad Sci, Inst Nucl Phys, Krakow, Poland.
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Paul Scherrer Inst, Villigen, Switzerland;Polish Acad Sci, Inst Nucl Phys, Krakow, Poland. Paul Scherrer Inst, Villigen, Switzerland.;Jan Kochanowski Univ Humanities & Sci, Inst Phys, Kielce, Poland. (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Biophysical Journal. - : Elsevier BV. - 0006-3495 .- 1542-0086. ; 110:6, s. 1304-1311
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The biological influence of radiation on living matter has been studied for years; however, several questions about the detailed mechanism of radiation damage formation remain largely unanswered. Among all biomolecules exposed to radiation, DNA plays an important role because any damage to its molecular structure can affect the whole cell and may lead to chromosomal rearrangements resulting in genomic instability or cell death. To identify and characterize damage induced in the DNA sugar-phosphate backbone, in this work we performed x-ray absorption spectroscopy at the P K-edge on DNA irradiated with either UVA light or protons. By combining the experimental results with theoretical calculations, we were able to establish the types and relative ratio of lesions produced by both UVA and protons around the phosphorus atoms in DNA.
Subject headings
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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