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Higher resting-stat...
Higher resting-state activity in reward-related brain circuits in obese versus normal-weight females independent of food intake
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- Hogenkamp, Pleunie S. (författare)
- Uppsala universitet,Funktionell farmakologi
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- Zhou, Wei (författare)
- Uppsala universitet,Funktionell farmakologi
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- Dahlberg, Linda Solstrand (författare)
- Uppsala universitet,Funktionell farmakologi
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- Stark, J. (författare)
- Uppsala universitet,Funktionell farmakologi
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- Larsen, A. L. (författare)
- Uppsala universitet,Funktionell farmakologi
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- Olivo, Gaia (författare)
- Uppsala universitet,Funktionell farmakologi
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- Wiemerslage, Lyle (författare)
- Uppsala universitet,Funktionell farmakologi
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- Larsson, Elna-Marie (författare)
- Uppsala universitet,Radiologi
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- Sundbom, Magnus (författare)
- Uppsala universitet,Gastrointestinalkirurgi
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- Benedict, Christian (författare)
- Uppsala universitet,Funktionell farmakologi
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- Schiöth, Helgi B. (författare)
- Uppsala universitet,Funktionell farmakologi
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(creator_code:org_t)
- 2016-06-07
- 2016
- Engelska.
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Ingår i: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 40:11, s. 1687-1692
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: In response to food cues, obese vs normal-weight individuals show greater activation in brain regions involved in the regulation of food intake under both fasted and sated conditions. Putative effects of obesity on task-independent low-frequency blood-oxygenation-level-dependent signals-that is, resting-state brain activity-in the context of food intake are, however, less well studied.OBJECTIVE: To compare eyes closed, whole-brain low-frequency BOLD signals between severely obese and normal-weight females, as assessed by functional magnetic resonance imaging (fMRI).METHODS: Fractional amplitude of low-frequency fluctuations were measured in the morning following an overnight fast in 17 obese (age: 39±11 years, body mass index (BMI): 42.3±4.8 kg m(-)(2)) and 12 normal-weight females (age: 36±12 years, BMI: 22.7±1.8 kg m(-)(2)), both before and 30 min after consumption of a standardized meal (~260 kcal).RESULTS: Compared with normal-weight controls, obese females had increased low-frequency activity in clusters located in the putamen, claustrum and insula (P<0.05). This group difference was not altered by food intake. Self-reported hunger dropped and plasma glucose concentrations increased after food intake (P<0.05); however, these changes did not differ between the BMI groups.CONCLUSION: Reward-related brain regions are more active under resting-state conditions in obese than in normal-weight females. This difference was independent of food intake under the experimental settings applied in the current study. Future studies involving males and females, as well as utilizing repeated post-prandial resting-state fMRI scans and various types of meals are needed to further investigate how food intake alters resting-state brain activity in obese humans.International Journal of Obesity advance online publication, 28 June 2016; doi:10.1038/ijo.2016.105.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Hogenkamp, Pleun ...
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Zhou, Wei
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Dahlberg, Linda ...
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Stark, J.
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Larsen, A. L.
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Olivo, Gaia
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visa fler...
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Wiemerslage, Lyl ...
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Larsson, Elna-Ma ...
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Sundbom, Magnus
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Benedict, Christ ...
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Schiöth, Helgi B ...
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visa färre...
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