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Soluble fms-Like Ty...
Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio and Time to Delivery in Women With Suspected Preeclampsia
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Zeisler, Harald (författare)
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Llurba, Elisa (författare)
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Chantraine, Frederic (författare)
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Vatish, Manu (författare)
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Staff, Anne Cathrine (författare)
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- Sennstrom, Maria (författare)
- Karolinska Institutet
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- Olovsson, Matts (författare)
- Uppsala universitet,Obstetrik & gynekologi
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Brennecke, Shaun P. (författare)
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Stepan, Holger (författare)
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Allegranza, Deirdre (författare)
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Dinkel, Carina (författare)
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Schoedl, Maria (författare)
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Dilba, Peter (författare)
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Hund, Martin (författare)
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Verlohren, Stefan (författare)
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Obstetrics and Gynecology. - 0029-7844 .- 1873-233X. ; 128:2, s. 261-269
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To assess the association of a serum soluble fms-like tyrosine kinase 1-to-placental growth factor (sFlt-1-to-PlGF) ratio of greater than 38 with time to delivery and preterm birth.METHODS: Secondary analysis of an observational cohort study that included women 18 years of age or older from 24 to 36 6/7 weeks of gestation at their first study visit with suspected (not confirmed) preeclampsia. Participants were recruited from December 2010 to January 2014 at 30 sites in 14 countries. A total of 1,041 women were included in time-to-delivery analysis and 848 in preterm birth analysis.RESULTS: Women with an sFlt-1-to-PlGF ratio greater than 38 (n=250) had a 2.9-fold greater likelihood of imminent delivery (ie, delivery on the day of the test) (Cox regression hazard ratio 2.9; P <.001) and shorter remaining time to delivery (median 17 [interquartile range 10-26] compared with 51 [interquartile range 3075] days, respectively; Weibull regression factor 0.62; P <.001) than women with an sFlt-1-to-PlGF ratio of 38 or less, whether or not they developed preeclampsia. For women who did not (n=842) and did develop preeclampsia (n=199), significant correlations were seen between an sFlt-1-to-PlGF ratio greater than 38 and preterm birth (r=0.44 and r=0.46; both P <.001). Among women who did not develop preeclampsia, those who underwent iatrogenic preterm delivery had higher median sFlt-1-to-PlGF ratios at their first visit (35.3, interquartile range 6.8-104.0) than those who did not (8.4, interquartile range 3.4-30.6) or who delivered at term (4.3, interquartile range 2.4-10.9).CONCLUSIONS: In women undergoing evaluation for suspected preeclampsia, a serum sFlt-1-to-PlGF ratio greater than 38 is associated with a shorter remaining pregnancy duration and a higher risk of preterm delivery.
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Zeisler, Harald
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Llurba, Elisa
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Chantraine, Fred ...
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Vatish, Manu
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Staff, Anne Cath ...
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Sennstrom, Maria
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visa fler...
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Olovsson, Matts
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Brennecke, Shaun ...
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Stepan, Holger
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Allegranza, Deir ...
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Dinkel, Carina
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Schoedl, Maria
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Dilba, Peter
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Hund, Martin
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Verlohren, Stefa ...
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visa färre...
- Artiklar i publikationen
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Obstetrics and G ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet