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High Concentrations...
High Concentrations of the Angiogenic Peptide VEGF-A in Seminal Fluid and its Association to Prostasomes
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- Carlsson, Lena (författare)
- Uppsala universitet,Biokemisk struktur och funktion
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- Ronquist, Gunnar (författare)
- Uppsala universitet,Biokemisk struktur och funktion
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- Elisasson, Rune (författare)
- Sophia Hosp, Androl Lab, Stockholm, Sweden.
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- Dubois, Louise (författare)
- Uppsala universitet,Biokemisk struktur och funktion
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- Ronquist, Karl Göran (författare)
- Uppsala universitet,Biokemisk struktur och funktion
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- Larsson, Anders (författare)
- Uppsala universitet,Biokemisk struktur och funktion
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Clinical Laboratory. - 1433-6510. ; 62:8, s. 1515-1520
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.7...
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Abstract
Ämnesord
Stäng
- Background: Angiogenesis is the formation of new blood vessels by capillary sprouting from pre-existing vessels. This process is associated with increased expression of angiogenic factors like vascular endothelial growth factor (VEGF). The VEGF family consists of five members denoted VEGF-A, B, C, D and placenta growth factor (PlGF). Prostasomes are exosome-like extracellular vesicles existing in seminal plasma. The present study aimed at investigating the possible relationship between VEGF-A in seminal fluid and blood plasma and the prostasomal association of VEGF-A.Methods: Measurement of VEGF-A concentrations was carried out in seminal plasma from 40 males and in blood plasma from 40 male blood donors utilizing commercial ELISA kits. The prostasomal association of VEGF-A was investigated by flow cytometry.Results: We found highly elevated concentrations of VEGF-A in seminal fluid (median value 150000 pg/mL) compared with those of blood plasma. Flow cytometric analysis showed that VEGF-A is bound to the surface of prostasomes.Conclusions: Prostasomes and seminal plasma contain the angiogenic factor VEGF-A in high concentrations exceeding that of blood plasma by 1000 times.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- angiogenesis factor
- ELISA
- prostasomes
- seminal fluid
- vascular endothelial growth factor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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