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Radiation dose dist...
Radiation dose distribution in coronary arteries in breast cancer radiotherapy
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- Nilsson, Greger (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Gavle Cent Hosp, Dept Oncol, Gavle, Sweden.;Visby Hosp, Sect Oncol, Visby, Sweden.
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- Nyström, Petra Witt (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Isacsson, Ulf (författare)
- Uppsala universitet,Medicinsk strålningsvetenskap
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- Garmo, Hans (författare)
- Kings Coll London, Fac Life Sci & Med, Div Canc Studies, Guys Campus, London, England.;Uppsala Univ, Univ Hosp, Reg Canc Ctr, Uppsala, Sweden.
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- Duvernoy, Olov (författare)
- Uppsala universitet,Radiologi
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- Sjögren, Iwar (författare)
- Falun Cent Hosp, Dept Cardiol, Falun, Sweden.
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- Lagerqvist, Bo (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Holmberg, Lars (författare)
- Uppsala universitet,Endokrinkirurgi,Kings Coll London, Fac Life Sci & Med, Div Canc Studies, Guys Campus, London, England.
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- Blomqvist, Carl (författare)
- Univ Orebro, Univ Hosp, Dept Oncol, Orebro, Sweden.
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 55:8, s. 959-963
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Women irradiated for left-sided breast cancer (BC) have an increased risk of coronary artery disease compared to women with right-sided BC. We describe the distribution of radiation dose in segments of coronary arteries in women receiving adjuvant radiotherapy (RT) for left- or right-sided BC.Material and methods: Fifteen women with BC, seven left-sided and eight right-sided, who had received three-dimensional conformal radiotherapy (3DCRT), constituted the study base. The heart and the segments of the coronary arteries were defined as separate organs at risk (OAR), and the mean and maximum radiation doses were calculated for each OAR.Results: In women with left-sided BC, irrespective of if regional lymph node RT was given or not, maximum dose in mid and distal left anterior descending artery (mdLAD) was approximately 50Gy in 6/7 patients, whereas women with right-sided BC mainly received low doses of radiation. In women with left-sided BC, 6/7 patients had substantially higher mean dose to the distal LAD than to the heart, ranging from 30 to 55Gy and 3 to13Gy, respectively.Conclusion: We found a pronounced difference of radiation dose distribution in the coronary arteries between women with left- and right-sided BC. Women with left-sided BC had almost full treatment dose in parts of mdLAD, regardless of if regional lymph node irradiation was given or not, while women with right-sided BC mainly received low doses to the coronary arteries.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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