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High Maternal Body ...
High Maternal Body Mass Index in Early Pregnancy and Risks of Stillbirth and Infant Mortality-A Population-Based Sibling Study in Sweden
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- Lindam, Anna (författare)
- Karolinska Inst, Stockholm, Sweden.
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- Johansson, Stefan (författare)
- Karolinska Institutet
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- Stephansson, Olof (författare)
- Karolinska Institutet
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- Wikström, Anna-Karin (författare)
- Karolinska Institutet,Uppsala universitet,Obstetrik & gynekologi,Karolinska Inst, Stockholm, Sweden.
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- Cnattingius, Sven (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Stockholm, Sweden (creator_code:org_t)
- 2016-06-29
- 2016
- Engelska.
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Ingår i: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 184:2, s. 98-105
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https://academic.oup...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In a population-based case-control study, we investigated whether familial confounding influenced the associations between maternal overweight/obesity and risks of stillbirth and infant mortality by including both population and sister controls. Using nationwide data from the Swedish Medical Birth Register (1992-2011), we included all primiparous women with singleton births who also had a sister with a first birth during that time period. We used logistic regression analyses to calculate odds ratios (and 95% confidence intervals) adjusted for maternal age, height, smoking habits, education, and time period (5-year groups) of child's birth. Body mass index (BMI) was calculated as weight (kg)/height (m)(2). Compared with population controls with a normal BMI (18.5-24.9), stillbirth risk increased with increasing BMI (BMI 25-29.9: odds ratio (OR) = 1.51 (95% confidence interval (CI): 1.21, 1.89); BMI 30-34.9: OR = 1.77 (95% CI: 1.24, 2.50); BMI a parts per thousand yen35: OR = 3.16 (95% CI: 2.10, 4.76)). The sister case-control analyses revealed similar results. Offspring of obese women (BMI a parts per thousand yen30) had an increased risk of infant mortality when population controls were used (OR = 2.41, 95% CI: 1.83, 3.16), and an even higher risk was obtained when sister controls were used (OR = 4.04, 95% CI: 2.25, 7.25). We conclude that obesity in early pregnancy is associated with increased risks of stillbirth and infant mortality independently of genetic and early environmental risk factors shared within families.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- body mass index
- familial confounding
- infant mortality
- neonatal mortality
- postneonatal mortality
- sibling-design studies
- stillbirth
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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