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Sökning: id:"swepub:oai:DiVA.org:uu-307539" > Neurally adjusted v...

Neurally adjusted ventilatory assist in patients with acute respiratory failure : study protocol for a randomized controlled trial

Villar, Jesus (författare)
Inst Salud Carlos III, CIBER Enfermedades Resp, Monforte de Lemos 3-5,Pabellon 11, Madrid 28029, Spain.;Hosp Univ Dr Negrin, Multidisciplinary Organ Dysfunct Evaluat Res Netw, Res Unit, Barranco Ballena S-N,4th Floor South Wing, Las Palmas Gran Canaria 35019, Spain.;St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr Biomed Sci, 30 Bond St, Toronto, ON M5B 1W8, Canada.
Belda, Javier (författare)
Hosp Clin Univ Valencia, Dept Anesthesiol, Avda Blasco Ibanez 17, Valencia 46010, Spain.
Blanco, Jesus (författare)
Inst Salud Carlos III, CIBER Enfermedades Resp, Monforte de Lemos 3-5,Pabellon 11, Madrid 28029, Spain.;Hosp Univ Rio Hortega, Intens Care Unit, Calle Dulzaina 2, Valladolid 47012, Spain.
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Suarez-Sipmann, Fernando (författare)
Uppsala universitet,Hedenstiernalaboratoriet,Inst Salud Carlos III, CIBER Enfermedades Resp, Monforte de Lemos 3-5,Pabellon 11, Madrid 28029, Spain.;Univ Uppsala Hosp, Hedenstierna Lab, Dept Surg Sci, Akad Sjukhuset, Ing 40,Tr 3, SE-75185 Uppsala, Sweden.
Manuel Anon, Jose (författare)
Hosp Virgen de La Luz, Intens Care Unit, Hermandad de Donantes Sangre S-N, Cuenca 16002, Spain.
Perez-Mendez, Lina (författare)
Inst Salud Carlos III, CIBER Enfermedades Resp, Monforte de Lemos 3-5,Pabellon 11, Madrid 28029, Spain.;Hosp Univ NS Candelaria, Res Unit, Div Clin Epidemiol & Biostat, Carretera Gen Rosario 145, Santa Cruz De Tenerife 38010, Spain.
Ferrando, Carlos (författare)
Hosp Clin Univ Valencia, Dept Anesthesiol, Avda Blasco Ibanez 17, Valencia 46010, Spain.
Parrilla, Dacil (författare)
Hosp Univ NS Candelaria, Intens Care Unit, Carretera Gen Rosario 145, Santa Cruz De Tenerife 38010, Spain.
Montiel, Raquel (författare)
Hosp Univ NS Candelaria, Intens Care Unit, Carretera Gen Rosario 145, Santa Cruz De Tenerife 38010, Spain.
Corpas, Ruth (författare)
Hosp Gen NS Prado, Intens Care Unit, Carretera Madrid,Km 114, Talavera De La Reina, Toledo, Spain.
Gonzalez-Higueras, Elena (författare)
Hosp Virgen de La Luz, Intens Care Unit, Hermandad de Donantes Sangre S-N, Cuenca 16002, Spain.
Pestana, David (författare)
Hosp Univ Ramon y Cajal, Dept Anesthesiol, Carretera Colmenar Viejo,Km 9,100, Madrid 28034, Spain.
Martinez, Domingo (författare)
Hosp Univ Virgen de la Arrixaca, Intens Care Unit, Carretera Madrid Cartagena S-N, Murcia 30120, Spain.
Fernandez, Lorena (författare)
Soro, Marina (författare)
Hosp Clin Univ Valencia, Dept Anesthesiol, Avda Blasco Ibanez 17, Valencia 46010, Spain.
Angel Garcia-Bello, Miguel (författare)
Hosp Univ Dr Negrin, Div Biostat, Res Unit, Barranco Ballena S-N, Las Palmas Gran Canaria 35019, Spain.
Lidia Fernandez, Rosa (författare)
Inst Salud Carlos III, CIBER Enfermedades Resp, Monforte de Lemos 3-5,Pabellon 11, Madrid 28029, Spain.;Hosp Univ Dr Negrin, Multidisciplinary Organ Dysfunct Evaluat Res Netw, Res Unit, Barranco Ballena S-N,4th Floor South Wing, Las Palmas Gran Canaria 35019, Spain.
Kacmarek, Robert M. (författare)
Massachusetts Gen Hosp, Dept Resp Care, 55 Fruit St, Boston, MA 02114 USA.;Harvard Univ, Dept Anesthesiol, 55 Fruit St Gray Bigelow 444, Boston, MA 02144 USA.
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Inst Salud Carlos III, CIBER Enfermedades Resp, Monforte de Lemos 3-5,Pabellon 11, Madrid 28029, Spain;Hosp Univ Dr Negrin, Multidisciplinary Organ Dysfunct Evaluat Res Netw, Res Unit, Barranco Ballena S-N,4th Floor South Wing, Las Palmas Gran Canaria 35019, Spain.;St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr Biomed Sci, 30 Bond St, Toronto, ON M5B 1W8, Canada. Hosp Clin Univ Valencia, Dept Anesthesiol, Avda Blasco Ibanez 17, Valencia 46010, Spain. (creator_code:org_t)
2016-10-13
2016
Engelska.
Ingår i: Trials. - : Springer Science and Business Media LLC. - 1745-6215. ; 17
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://trialsjourna...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Patient-ventilator asynchrony is a common problem in mechanically ventilated patients with acute respiratory failure. It is assumed that asynchronies worsen lung function and prolong the duration of mechanical ventilation (MV). Neurally Adjusted Ventilatory Assist (NAVA) is a novel approach to MV based on neural respiratory center output that is able to trigger, cycle, and regulate the ventilatory cycle. We hypothesized that the use of NAVA compared to conventional lung-protective MV will result in a reduction of the duration of MV. It is further hypothesized that NAVA compared to conventional lung-protective MV will result in a decrease in the length of ICU and hospital stay, and mortality. Methods/design: This is a prospective, multicenter, randomized controlled trial in 306 mechanically ventilated patients with acute respiratory failure from several etiologies. Only patients ventilated for less than 5 days, and who are expected to require prolonged MV for an additional 72 h or more and are able to breathe spontaneously, will be considered for enrollment. Eligible patients will be randomly allocated to two ventilatory arms: (1) conventional lung-protective MV (n = 153) and conventional lung-protective MV with NAVA (n = 153). Primary outcome is the number of ventilator-free days, defined as days alive and free from MV at day 28 after endotracheal intubation. Secondary outcomes are total length of MV, and ICU and hospital mortality. Discussion: This is the first randomized clinical trial examining, on a multicenter scale, the beneficial effects of NAVA in reducing the dependency on MV of patients with acute respiratory failure.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

Nyckelord

Acute respiratory failure
Neurally adjusted ventilatory assist
Ventilator-free days
Lung-protective ventilation
Assist ventilation
Liberation from mechanical ventilation

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