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Diabetes Prevention...
Diabetes Prevention Through Antiviral Treatment in Biobreeding Rats
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- Niklasson, Bo (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Arbrandt, Gustav (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Kawecki, Anne (författare)
- Karolinska Univ Hosp, Dept Pathol, Stockholm, Sweden.
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- Juntti-Berggren, Lisa (författare)
- Karolinska Institutet
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- Berggren, Per-Olof (författare)
- Karolinska Institutet
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- Al-Qahtani, Saad Misfer (författare)
- Karolinska Institutet
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- Gustafsson, Anna-Lena (författare)
- Karolinska Univ Hosp, Dept Comparat Med, Stockholm, Sweden.
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- Bryzgalova, Galyna (författare)
- Karolinska Institutet
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- Klitz, William (författare)
- Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA.
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(creator_code:org_t)
- Mary Ann Liebert Inc, 2016
- 2016
- Engelska.
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Ingår i: Viral immunology. - : Mary Ann Liebert Inc. - 0882-8245 .- 1557-8976. ; 29:8, s. 452-458
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- A picornavirus (Ljungan virus) has been associated with diabetes in its wild rodent reservoir and in diabetesprone biobreeding (DP-BB) rats. We attempted to alter the development of diabetes in DP-BB rats using two anti-picornavirus compounds (pleconaril and APO-N039), singly or in combination. Antiviral therapy was initiated 2 weeks before expected onset of diabetes. Pleconaril or APO-N039 alone did not affect the debut of diabetes. However, animals receiving a combination of both compounds were protected for at least the entire period of treatment (4 weeks after expected time of diabetes onset). Immunohistochemistry demonstrated that the presence and distribution of virus antigen in the pancreatic islets coincided with the clinical status of the animal. Data indicate that a treatable picornavirus can be involved in the cellular assault resulting in diabetes and in these cases the disease mechanism appears to involve a virus present in the pancreatic beta cell mass itself.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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